2-溴-α-麦角隐亭甲磺酸盐

Description

2-bromo-alpha-ergocryptine methane-sulfonate · CAS 22260-51-1 · C33H44BrN5O8S. UNII FFP983J3OD.

Identification

CAS Registry Number	22260-51-1
PubChem CID	31100
Molecular formula	C33H44BrN5O8S
IUPAC name	(6aR,9R)-5-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
UNII (FDA)	FFP983J3OD

Computed Descriptors

Molecular Weight	750.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	749.20940
Monoisotopic Mass	749.20940
Topological Polar Surface Area	181
Heavy Atom Count	48
Formal Charge	0
Complexity	1320

Physical description & handling notes

• 244.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (45.5%), H332 (36.4%), H361 (45.5%), H362 (18.2%), H400 (45.5%), H410 (72.7%)

Documented Uses

• Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
• Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
• Drugs that bind to and activate dopamine receptors.
• Ergot Derivative [EPC]; Ergolines [CS]
• Completely metabolized by the liver, primarily by hydrolysis of the amide bond to produce lysergic acid and a peptide fragment, both inactive and non-toxic. Bromocriptine is metabolized by cytochrome P450 3A4 and excreted primarily in the feces via biliary secretion. Route of Elimination: Parent drug and metabolites are almost completely excreted via the liver, and only 6% eliminated via the kidney. Half Life: 2-8 hours

Synonyms

BROMOCRIPTINE MESYLATE; 22260-51-1; Bromocriptine mesilate; Pravidel; Cycloset; Bagren; Bromocriptine methanesulfonate; CB-154 mesylate; Cb-154 mesilate; 2-Bromoergocryptine Mesylate; 2-Bromo-alpha-ergocryptine mesylate; DTXSID6020197; FFP983J3OD; NSC-755915; DTXCID00197; CHEBI:3182

Frequently Asked Questions

What are the CAS number and molecular formula of 2-bromo-alpha-ergocryptine methane-sulfonate?

CAS 22260-51-1; molecular formula C33H44BrN5O8S; molecular weight — g/mol.

What other names is 2-bromo-alpha-ergocryptine methane-sulfonate known by?

BROMOCRIPTINE MESYLATE, 22260-51-1, Bromocriptine mesilate, Pravidel, Cycloset, Bagren.

Is 2-bromo-alpha-ergocryptine methane-sulfonate classified as hazardous?

Hazard statements reported: H302, H332, H361, H362, H400.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.