3,5-dihydroxy-3-methylvaleric acid

Description

3,5-dihydroxy-3-methylvaleric acid · CAS 150-97-0 · C6H12O4. UNII S5UOB36OCZ.

Identification

Computed Descriptors

Physical description & handling notes

• Oily liquid
• Very soluble in water, but also soluble in organic solvents, especially polar organic solvents.
• Crystals from benzene + petroleum ether, mp 96-97 °C. Specific optical rotation: -20 deg at 20 °C/D (c = 2 in ethanol) /Benzhydrylamide/
• Hygroscopic crystals, mp 28 °C /delta-Lactone/

Documented Uses

• ... An inhibitor of cholesterol synthesis
• The self-condensation of two molecules of acetyl coenzyme A (CoA) forms acetoacetyl CoA. Condensation of acetoacetyl CoA with a third molecule of acetyl CoA, then followed by an NADPH-mediated reduction of the thioester moiety produces mevalonic acid.
• Precursor in the biosynthesis of cholesterol
• /EXPL/ Twenty eight patients with heterozygous familial hypercholesterolemia were treated with mevalonic acid (an inhibitor of cholesterol synthesis) for 45 days. Patients received a daily dose of 750 to 1500 mg mevalonic acid depending on plasma cholesterol levels. Results showed a significant reduction in cholesterol values whereas no significant difference was observed in HDL cholesterol and triglyceride levels.
• Mevalonic acid is an intermediate after the rate-limiting step in cholesterol biosynthesis, which is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme A reductase.
• The mevalonate pathway is an important metabolic pathway which plays a key role in multiple cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol isoprenoids, such as dolichol, heme-A, isopentenyl tRNA...

Synonyms

150-97-0; DL-Mevalonic acid; Hiochic acid; Pentanoic acid, 3,5-dihydroxy-3-methyl-; S5UOB36OCZ; Acid, Mevalonic; DTXSID5040546; CHEBI:25351; RefChem:818790; DTXCID10209648; 3,5-Dihydroxy-3-methylvaleric acid; Mevalonic Acid; 3,5-dihydroxy-3-methylpentanoic acid; (RS)-mevalonate; 3,5-Dihydroxy-3-methyl-pentanoic acid; (RS)-MEVALONIC ACID

Frequently Asked Questions

What are the CAS number and molecular formula of 3,5-dihydroxy-3-methylvaleric acid?

CAS 150-97-0; molecular formula C6H12O4; molecular weight — g/mol.

What other names is 3,5-dihydroxy-3-methylvaleric acid known by?

150-97-0, DL-Mevalonic acid, Hiochic acid, Pentanoic acid, 3,5-dihydroxy-3-methyl-, S5UOB36OCZ, Acid, Mevalonic.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.