a-Methyl-L-p-tryosine

Description

a-Methyl-L-p-tryosine · CAS 672-87-7 · C10H13NO3. UNII DOQ0J0TPF7. Melting Point: 312.5; Melting Point: 312.5 °C; Solubility: 2.48e+00 g/L.

Identification

CAS Registry Number	672-87-7
PubChem CID	441350
Molecular formula	C10H13NO3
IUPAC name	(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
UNII (FDA)	DOQ0J0TPF7

Computed Descriptors

Molecular Weight	195.21
XLogP3	-1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	195.08954328
Monoisotopic Mass	195.08954328
Topological Polar Surface Area	83.6
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	312.5
Melting Point	312.5 °C
Solubility	2.48e+00 g/L
LogP	-1.7

Physical description & handling notes

• Solid
• Very slightly soluble

GHS Hazard Classification

Reported hazard statements	H302 (100%), H335 (100%)

Documented Uses

• For use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma.
• Avoid alcohol. Ingesting alcohol may increase the sedative and CNS depressant effects of metyrosine.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
• Established Pharmacologic Class [EPC] - Catecholamine Synthesis Inhibitor
• Mechanisms of Action [MoA] - Catecholamine Synthesis Inhibitors
• Metyrosine is a Catecholamine Synthesis Inhibitor. The mechanism of action of metyrosine is as a Catecholamine Synthesis Inhibitor.

Synonyms

METYROSINE; 672-87-7; Metirosine; Demser; Metirosina; (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (S)-alpha-Methyltyrosine; L-alpha-Methyltyrosine; Metirosinum; (-)-alpha-Methyl-L-tyrosine; Alpha-Methyl-L-P-Tyrosine; MK-781; DTXSID6023315; DOQ0J0TPF7; CHEBI:6912; L-588357-0

Frequently Asked Questions

What are the CAS number and molecular formula of a-Methyl-L-p-tryosine?

CAS 672-87-7; molecular formula C10H13NO3; molecular weight — g/mol.

What other names is a-Methyl-L-p-tryosine known by?

METYROSINE, 672-87-7, Metirosine, Demser, Metirosina, (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid.

Is a-Methyl-L-p-tryosine classified as hazardous?

Hazard statements reported: H302, H335.

What are the key physical properties of a-Methyl-L-p-tryosine?

Melting Point: 312.5; Melting Point: 312.5 °C; Solubility: 2.48e+00 g/L; LogP: -1.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.