Adefovir Dipivoxyl

Description

Adefovir Dipivoxyl · CAS 142340-99-6 · C20H32N5O8P. UNII U6Q8Z01514. Solubility: 19; Solubility: 6.33e-01 g/L; LogP: 1.91.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

GHS Hazard Classification

Documented Uses

• Take with or without food. The absorption is unaffected by food.
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
• Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
• Nucleoside Analog [EXT]; Nucleoside Reverse Transcriptase Inhibitors [MoA]; Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
• J - Antiinfectives for systemic use
• J05 - Antivirals for systemic use

Synonyms

ADEFOVIR DIPIVOXIL; 142340-99-6; Hepsera; Adefovir pivoxil; GS-0840; GS 0840; DTXSID5046487; Adefovir di(pivaloyloxymethyl) ester; 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate; U6Q8Z01514; DTXCID3026487; CHEBI:31175; adefovir depivoxil; RefChem:56260

Frequently Asked Questions

What are the CAS number and molecular formula of Adefovir Dipivoxyl?

CAS 142340-99-6; molecular formula C20H32N5O8P; molecular weight — g/mol.

What other names is Adefovir Dipivoxyl known by?

ADEFOVIR DIPIVOXIL, 142340-99-6, Hepsera, Adefovir pivoxil, GS-0840, GS 0840.

Is Adefovir Dipivoxyl classified as hazardous?

Hazard statements reported: H302, H312, H332, H311, H331.

What are the key physical properties of Adefovir Dipivoxyl?

Solubility: 19; Solubility: 6.33e-01 g/L; LogP: 1.91; LogP: 0.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.