盐酸艾乐替尼

Description

Alectinib hydrochloride · CAS 1256589-74-8 · C30H34N4O2. UNII LIJ4CT1Z3Y. Dissociation Constants: 7.05.

Identification

CAS Registry Number	1256589-74-8
PubChem CID	49806720
Molecular formula	C30H34N4O2
IUPAC name	9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
UNII (FDA)	LIJ4CT1Z3Y

Computed Descriptors

Molecular Weight	482.6
XLogP3	5.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	482.26817634
Monoisotopic Mass	482.26817634
Topological Polar Surface Area	72.4
Heavy Atom Count	36
Formal Charge	0

Physical & Chemical Properties

Dissociation Constants	7.05

Regulatory Status

GHS notification summary	66.7% (2 / 3)

GHS Hazard Classification

GHS notification summary	66.7% (2 / 3)
Reported hazard statements	H341 (33.3%), H361 (33.3%), H373 (33.3%)

Documented Uses

• Alectinib is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It is also indicated as an adjuvant treatment in adult patients following tumor resection of ALK-positive non-small cell lung cancer.
• Alectinib is a tyrosine kinase receptor inhibitor and antineoplastic agent used in the therapy of selected forms of non-small cell lung cancer. Alectinib is associated with a high rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Alectinib is approved to treat adults with:
• • Non-small cell lung cancer(NSCLC) that is ALK positive. It is used:
• • To prevent NSCLC from coming back after it was removed by surgery.

Synonyms

Alectinib; 1256580-46-7; CH5424802; CH 5424802; AF-802; RO5424802; CH-5424802; AF802; 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile; AF 802; LIJ4CT1Z3Y; RO-5424802; CHEBI:90936; DTXSID50154840; RG7853; 9-ETHYL-6,6-DIMETHYL-8-[4-(MORPHOLIN-4-YL)PIPERIDIN-1-YL]-11-OXO-5H,6H,11H-BENZO[B]CARBAZOLE-3-CARBONITRILE

Frequently Asked Questions

What are the CAS number and molecular formula of Alectinib hydrochloride?

CAS 1256589-74-8; molecular formula C30H34N4O2; molecular weight — g/mol.

What other names is Alectinib hydrochloride known by?

Alectinib, 1256580-46-7, CH5424802, CH 5424802, AF-802, RO5424802.

Is Alectinib hydrochloride classified as hazardous?

66.7% of GHS notifications report no hazard classification (2 of 3).

What are the key physical properties of Alectinib hydrochloride?

Dissociation Constants: 7.05.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.