碱性磷酸酶

Description

Alkaline Phosphatase · CAS 9001-78-9 · C21H36N8O6.

Identification

CAS Registry Number	9001-78-9
PubChem CID	18985873
Molecular formula	C21H36N8O6
IUPAC name	2-[[1-[2-[[1-(2-aminopropanoyl)pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid

Computed Descriptors

Molecular Weight	496.6
XLogP3	-5
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	11
Exact Mass	496.27578090
Monoisotopic Mass	496.27578090
Topological Polar Surface Area	227
Heavy Atom Count	35
Formal Charge	0

Physical description & handling notes

• Powder; [Sigma-Aldrich MSDS]
• Patients with UC have reduced AP levels and activity in the inflamed tissue in the intestines. A short treatment with AP helps to restore the intestinal mucosal barrier in UC patients, which can be classified as a disease modifying antiinflammatory effect.

Regulatory Status

GHS notification summary	100% (2 / 2)

GHS Hazard Classification

GHS notification summary	100% (2 / 2)

Documented Uses

• Investigated for use/treatment in ulcerative colitis.
• Two substrates that can disturb the homeostasis in human organs are endotoxin from Gram-negative bacteria (LPS) and adenosine triphosphate (ATP). Dephosphorylation of LPS and extracellular ATP by AP has been shown to result in restoration of homeostasis in the target organs such as GI tract and kidney, through reduction of inflammationinduced damage. In the gastrointestinal tract, the prime source of LPS is derived from the residing Gram-negative microorganisms. In UC patients the mucosal surface of the colon wall

Synonyms

Alkaline phosphatase; Phosphatase, alkaline; RefChem:388781; DTXSID4093801; EINECS 232-631-4; Phosphatase, Alkaline, from Escherichia coli; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Orthophosphoricmonoester phosphohydrolase (alkaline optimum); 232-631-4; 9001-78-9; Phosphatase, Alkaline from Escherichia coli; Enterostatin, human, mouse, rat; ENTEROSTATIN,HUMAN; Alkaline Phosphatase (ALP); ITZMJCSORYKOSI-UHFFFAOYSA-N; Alkaline Phosphatase from calf intestinal

Frequently Asked Questions

What are the CAS number and molecular formula of Alkaline Phosphatase?

CAS 9001-78-9; molecular formula C21H36N8O6; molecular weight — g/mol.

What other names is Alkaline Phosphatase known by?

Alkaline phosphatase, Phosphatase, alkaline, RefChem:388781, DTXSID4093801, EINECS 232-631-4, Phosphatase, Alkaline, from Escherichia coli.

Is Alkaline Phosphatase classified as hazardous?

100% of GHS notifications report no hazard classification (2 of 2).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.