阿格列汀

Description

Alogliptin · CAS 850649-61-5 · C18H21N5O2. UNII JHC049LO86.

Identification

CAS Registry Number	850649-61-5
PubChem CID	11450633
Molecular formula	C18H21N5O2
IUPAC name	2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile
UNII (FDA)	JHC049LO86

Computed Descriptors

Molecular Weight	339.4
XLogP3	0.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	339.16952493
Monoisotopic Mass	339.16952493
Topological Polar Surface Area	93.7
Heavy Atom Count	25
Formal Charge	0

Physical description & handling notes

• Sparingly soluble
• Stable if stored as directed; avoid strong oxidizing agents
• Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
• White to off-white crystalline powder; soluble in dimethylsulfoxide; sparingly soluble in water, methanol; slightly soluble in ethanol; very slightly soluble in octanol, isopropyl acetate /Alogliptin benzoate/
• Table: Alogliptin benzoate Preparations [Table#8191]
• Table: Alogliptin benzoate Combinations Preparations [Table#8192]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
• Type 2 diabetes (T2D) is a chronic illness that is increasingly diagnosed among children and adults in the United States of America. According to the Centers for Disease Control and Prevention (CDC), approximately 100 million adults in the United States of America had either diabetes or prediabetes in 2015. T2D is the seventh leading cause of death and is associated with a 2- to 4-fold increased risk of cardiovascular disease. Effective glucose control is essential for managing the condition. The American Diabetes
• Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other oral hypoglycemic agents. Alogliptin has been reported to cause liver injury, but the characteristics and details of the injury have not been defined in the published literature.
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Incretins; Dipeptidyl-Peptidase IV Inhibitors; DPP-4 Inhibitors
• Alogliptin (Class: Other Substances, Added Date: 05-2015)
• Nesina is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings. /Included in US product label/

Synonyms

Alogliptin; 850649-61-5; alogliptina; alogliptine; vipidia; alogliptinum; JHC049LO86; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; HSDB 8203; CHEBI:72323; DTXSID90234130; 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile; alogliptin tartrate; 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; RefChem:57142; A10BH04

Frequently Asked Questions

What are the CAS number and molecular formula of Alogliptin?

CAS 850649-61-5; molecular formula C18H21N5O2; molecular weight — g/mol.

What other names is Alogliptin known by?

Alogliptin, 850649-61-5, alogliptina, alogliptine, vipidia, alogliptinum.

Is Alogliptin classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.