altretamine

Description

Hexamethylmelamine · CAS 645-05-6 · C9H18N6. UNII Q8BIH59O7H. Melting Point: 168; Melting Point: 172-174 °C; Melting Point: 172 - 174 °C.

Identification

CAS Registry Number	645-05-6
PubChem CID	2123
Molecular formula	C9H18N6
IUPAC name	2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
UNII (FDA)	Q8BIH59O7H

Computed Descriptors

Molecular Weight	210.28
XLogP3	2.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	210.15929460
Monoisotopic Mass	210.15929460
Topological Polar Surface Area	48.4
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Melting Point	168
Melting Point	172-174 °C
Melting Point	172 - 174 °C
Solubility	91
Solubility	In water, 91 mg/L at 25 °C
Solubility	3.10e+00 g/L
Solubility	Water 0.92 (mg/mL)
Solubility	Benzene 106 (mg/mL)
Solubility	CHCL3 220 (mg/mL)
Solubility	EtOAc 52 (mg/mL)

Physical description & handling notes

• Hexamethylmelamine is a colorless crystalline solid. Insoluble in water. (NTP, 1992)
• Solid
• Needles from absolute ethanol
• Insoluble (NTP, 1992)
• Soluble in acetone
• Bulk: The bulk drug is stable at room temperature. Solution: Aqueous solutions at pH 4, 7, and 10 are stable for 24 hours at room temperature (UV).

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent based combination.
• Experimental insect chemosterilant.
• Production process: H. von Brachel, H. Kindler, DE 1240870; eidem, US 3424752 (1967, 1969 both to Casella Farbwerke)
• For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
• Altretamine is an orally administered alkylating agent, formerly known as hexamethylmelamine, which is currently used as a secondary therapy for advanced ovarian carcinoma. Altretamine therapy has been associated with low rates of serum enzyme elevations during therapy and with rare instances of acute, clinically apparent injury.
• Antineoplastic Agents, Alkylating Agents

Synonyms

altretamine; 645-05-6; HEXAMETHYLMELAMINE; Hexalen; Hexastat; Hemel; Altretamina; Melamine, hexamethyl-; Altretaminum; ENT 50852; 2,4,6-Tris(dimethylamino)-s-triazine; NCI-C50259; 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine; NSC 13875; NSC-13875; DTXSID4022579

Frequently Asked Questions

What are the CAS number and molecular formula of Hexamethylmelamine?

CAS 645-05-6; molecular formula C9H18N6; molecular weight — g/mol.

What other names is Hexamethylmelamine known by?

altretamine, 645-05-6, HEXAMETHYLMELAMINE, Hexalen, Hexastat, Hemel.

Is Hexamethylmelamine classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of Hexamethylmelamine?

Melting Point: 168; Melting Point: 172-174 °C; Melting Point: 172 - 174 °C; Solubility: 91.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.