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Description

antazoline · CAS 91-75-8 · C17H19N3. UNII DHA8014SS1. Melting Point: 227-229; Melting Point: 120-122 °C; Solubility: 663.

Identification

CAS Registry Number	91-75-8
PubChem CID	2200
Molecular formula	C17H19N3
IUPAC name	N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
UNII (FDA)	DHA8014SS1

Computed Descriptors

Molecular Weight	265.35
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	265.157897619
Monoisotopic Mass	265.157897619
Topological Polar Surface Area	27.6
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	227-229
Melting Point	120-122 °C
Solubility	663
Solubility	In water, 6.63X10+2 mg/L at 30 °C

Physical description & handling notes

• Solid
• White, crystalline powder
• Odorless
• Bitter
• Mol wt 301.82. Bitter crystals producing temporary numbness of the tongue. mp 237-241 °C. UV max: 242 nm (E 1% 1cm = 495 to 515); min 222 nm. One gram dissolves in 40 ml water, in 25 ml alc. Practically insol in ether, benzene, chloroform. pH (1% aq soln): 6.3. /Hydrochloride/
• Crystals. Bitter taste. mp 194-198 °C. Sol in water. Sparingly sol in methanol. Practically insol in benzene, ether. pH (2% aq soln): 4.5. /Phosphate/

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (97.5%), H315 (95%), H319 (95%), H335 (95%)

Documented Uses

• THERAP CAT (VET): Antihistaminic
• Prepared by the condensation of benzylaniline with 2-(chloromethyl)imidazoline.
• Used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
• Anti-Allergic Agents; Histamine H1 Antagonists
• Antazoline ... is an antihistamine used orally and also in eyedrops ...
• Antazoline is an ethylenediamine derivative with the properties and uses of the antihistamines. It is one of the least active of the commonly used antihistamines and has a short duration of action. It has local anaesthetic and also some anticholinergic properties. It is claimed to be less irritating to the tissue than most other antihistamines.

Synonyms

antazoline; 91-75-8; Phenazoline; Antihistal; Antastan; Antasten; Azalone; Antistine; Histostab; Imidamine; Antazolin; Antazolina; Antazolinum; Ben-A-hist; N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; 2-(N-Phenyl-N-benzylaminomethyl)imidazoline

Frequently Asked Questions

What are the CAS number and molecular formula of antazoline?

CAS 91-75-8; molecular formula C17H19N3; molecular weight — g/mol.

What other names is antazoline known by?

antazoline, 91-75-8, Phenazoline, Antihistal, Antastan, Antasten.

Is antazoline classified as hazardous?

Hazard statements reported: H302, H312, H315, H319, H335.

What are the key physical properties of antazoline?

Melting Point: 227-229; Melting Point: 120-122 °C; Solubility: 663; Solubility: In water, 6.63X10+2 mg/L at 30 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.