阿舒瑞韦

Description

Asunaprevir · CAS 630420-16-5 · C35H46ClN5O9S. UNII S9X0KRJ00S. Melting Point: 145-155 ºC; Solubility: <50 mg/L.

Identification

CAS Registry Number	630420-16-5
PubChem CID	16076883
Molecular formula	C35H46ClN5O9S
IUPAC name	tert-butyl N-[(2S)-1-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
UNII (FDA)	S9X0KRJ00S

Computed Descriptors

Molecular Weight	748.3
XLogP3	4.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	14
Exact Mass	747.2704769
Monoisotopic Mass	747.2704769
Topological Polar Surface Area	191
Heavy Atom Count	51
Formal Charge	0

Physical & Chemical Properties

Melting Point	145-155 ºC
Solubility	<50 mg/L

GHS Hazard Classification

Reported hazard statements	H373 (100%)

Documented Uses

• Asunaprevir is indicated in combination with other agents for the treatment of chronic hepatitis C in adult patients with hepatitis C virus genotypes 1 or 4 and compensated liver cirrhosis. Hepatitis C is a liver disease caused by the hepatitis C virus. The chronic state of this condition accounts for 60-80% of the cases from which the risk of cirrhosis of the liver within 20 years is of around 15-30%. The genotype 1 is the most common type of hepatitis C in the United States and the most difficult to treat.
• Avoid St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of asunaprevir. Co-administration of asunaprevir with St. John's Wort is contraindicated.
• Exercise caution with grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of asunaprevir.
• Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
• J - Antiinfectives for systemic use
• J05 - Antivirals for systemic use

Synonyms

Asunaprevir; 630420-16-5; BMS-650032; sunvepra; BMS 650032; BMS650032; S9X0KRJ00S; DTXSID201026065; asunaprevirum; RefChem:560284; J05AP06; DTXCID201510323; MFCD27987900; Asunaprevir [USAN]; C35H46ClN5O9S; Asunaprevir [USAN:INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Asunaprevir?

CAS 630420-16-5; molecular formula C35H46ClN5O9S; molecular weight — g/mol.

What other names is Asunaprevir known by?

Asunaprevir, 630420-16-5, BMS-650032, sunvepra, BMS 650032, BMS650032.

Is Asunaprevir classified as hazardous?

Hazard statements reported: H373.

What are the key physical properties of Asunaprevir?

Melting Point: 145-155 ºC; Solubility: <50 mg/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.