Description
Avilamycin · CAS 11051-71-1 · C61H88Cl2O32. UNII 720WDX56D3. Melting Point: 188-189.5 °C.
Identification
| CAS Registry Number | 11051-71-1 |
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| PubChem CID | 71674 |
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| Molecular formula | C61H88Cl2O32 |
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| UNII (FDA) | 720WDX56D3 |
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Computed Descriptors
| Molecular Weight | 1404.2 |
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| XLogP3 | 0.6 |
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| Hydrogen Bond Donor Count | 6 |
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| Hydrogen Bond Acceptor Count | 32 |
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| Rotatable Bond Count | 20 |
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| Exact Mass | 1402.4635760 |
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| Monoisotopic Mass | 1402.4635760 |
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| Topological Polar Surface Area | 385 |
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| Heavy Atom Count | 95 |
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| Formal Charge | 0 |
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Physical & Chemical Properties
| Melting Point | 188-189.5 °C |
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Physical description & handling notes
- Colorless, needle-shaped crystals from acetone-ether
- Colorless needles from chloroform/petroleum ether; MW: 1404.25; MP: 181-182 °C (1-2.H2O). UV max (methanol): 227, 286 nm (log epsilon 4.12, 3.33) /Avilamycin A/
- Specific optical rotation at 20 °C/D = +0.8 deg (c = 1.165 in absolute ethanol); -7.7 deg (c = 1.083 in chloroform)
- Oligosaccharide antibiotics are sensitive to acid pH because of the ortho-ester linkages. Acidic phenolic group makes them relatively unstable to handling conditions.
- Dihydrate; colorless fine plates from acetone/ether; MP: 188-189 °C. Specific optical rotation at 20 °C/D: -4.8 deg (C = 1.44 in chloroform). UV Max (methanol): 228, 284 nm (log epsilon 4.12, 3.33) /Avilamycin C/
- Reactive groups are the glycosidic linkages, the hydroxyl groups, the carbonyl groups, and the phenolic groups.
Regulatory Status
| Regulatory & Food Contact | ANTIMICROBIAL_AGENT: Veterinary Drug
JECFA ADI: 0-0.002 mg/kg bw
TRS 954- JECFA 70
Avilamycin.pdf |
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GHS Hazard Classification
| Reported hazard statements | H319 (100%) |
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H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Documented Uses
- Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
- Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
- Polyether antibiotic complex produced by Streptromyces viridochromogenes, ETH 23575 (NRRL 2860) ... Isoln: E. Gaeumann et al., German patent 1116864; eidem, USA patent 3131126 (1961, 1964 both to Ciba-Geigy).
- Avilamycin A is the main component; avilamycins B through N are also known and are derivatives of A differing at the C-45 linkage and/or the C-56 ketone adduct.
- MEDICATION (VET): Avilamycin is mainly active against Gram-positive bacteria, including Bacillus spp., Clostridium spp., Corynebacterium bovis, Enterococcus spp., Lactobacillus spp., Listeria monocytogenes, Micrococcus luteus, Staphylococcus aureus and Streptococcus spp. Avilamycin is intended for use as a veterinary medicine in chickens, turkeys, pigs and rabbits to control bacterial enteric infections.
- MEDICATION (VET): For the reduction in incidence and overall severity of diarrhea in the presence of pathogenic Escherichia coli in groups of weaned pigs. /Included in US product label/
Synonyms
Avilamycin; Avilamycina; Avilamycine; Avilamycinum; 11051-71-1; LY 048 740; DTXSID40891398; 720WDX56D3; avilamicina; Inteprity; Kavault; RefChem:57998; DTXCID701030518; LY-048740; Surmax; C61H88Cl2O32
Frequently Asked Questions
What are the CAS number and molecular formula of Avilamycin?
CAS 11051-71-1; molecular formula C61H88Cl2O32; molecular weight — g/mol.
What other names is Avilamycin known by?
Avilamycin, Avilamycina, Avilamycine, Avilamycinum, 11051-71-1, LY 048 740.
What is the regulatory status of Avilamycin?
Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; JECFA ADI: 0-0.002 mg/kg bw; TRS 954- JECFA 70.
Is Avilamycin classified as hazardous?
Hazard statements reported: H319.
What are the key physical properties of Avilamycin?
Melting Point: 188-189.5 °C.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
