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Axitinib

CAS 319460-85-0C22H18N4OSMW 386.5

Axitinib (CAS No. 319460-85-0) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number319460-85-0
Molecular FormulaC22H18N4OS
Molecular Weight386.5
LogP3.8
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Axitinib?

The CAS number of Axitinib is 319460-85-0.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Axitinib?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Axitinib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Axitinib · CAS 319460-85-0 · C22H18N4OS. UNII C9LVQ0YUXG. LogP: 3.8; Dissociation Constants: 4.8.

Identification

CAS Registry Number319460-85-0
PubChem CID6450551
Molecular formulaC22H18N4OS
IUPAC nameN-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
UNII (FDA)C9LVQ0YUXG

Computed Descriptors

Molecular Weight386.5
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass386.12013238
Monoisotopic Mass386.12013238
Topological Polar Surface Area96
Heavy Atom Count28
Formal Charge0

Physical & Chemical Properties

LogP3.8
Dissociation Constants4.8

Physical description & handling notes

  • In aqueous media with a pH between 1.1 to 7.8, axitinib has a solubility of over 0.2 μg/mL.
  • Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth.

GHS Hazard Classification

Reported hazard statementsH302 (53.4%), H341 (43.8%), H361 (43.8%), H373 (43.8%), H400 (56.2%)

H302 (53.4%): Harmful if swallowed [Warning Acute toxicity, oral]

H341 (43.8%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

Documented Uses

  • Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
  • • Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used:
  • • With avelumab or pembrolizumab as the first treatment.
  • • Alone in patients whose cancer did not get better after one treatment with systemic therapy.
  • Axitinib is also being studied in the treatment of other types of cancer.

Synonyms

Axitinib; 319460-85-0; Inlyta; AG-13736; axitinibum; C9LVQ0YUXG; DTXSID3049049; AG013736; NSC-757441; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; DTXCID8028975; CHEBI:66910; Benzamide, N-methyl-2-((3-((E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)thio)-; N-methyl-2-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazo)-6-yl)thio)-

Frequently Asked Questions

What are the CAS number and molecular formula of Axitinib?

CAS 319460-85-0; molecular formula C22H18N4OS; molecular weight — g/mol.

What other names is Axitinib known by?

Axitinib, 319460-85-0, Inlyta, AG-13736, axitinibum, C9LVQ0YUXG.

Is Axitinib classified as hazardous?

Hazard statements reported: H302, H341, H361, H373, H400.

What are the key physical properties of Axitinib?

LogP: 3.8; Dissociation Constants: 4.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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