阿折地平

Name: 阿折地平
Brand: 济南圣和化工有限公司

CAS 123524-52-7C33H34N4O6MW 582.6

阿折地平，CAS 登记号 123524-52-7，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于医药中间体及原料药。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号123524-52-7

分子式C33H34N4O6

分子量582.6

熔点193-195

LogP5.18

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域医药中间体及原料药

类别医药中间体及原料药

用途与场景

医药中间体及原料药

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

文件与支持

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常见问题

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阿折地平一般用在什么产品里？

主要涉及医药中间体及原料药。

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PubChem 公开数据

Description

Azelnidipine · CAS 123524-52-7 · C33H34N4O6. UNII PV23P19YUG. Melting Point: 193-195; LogP: 5.18.

Identification

CAS Registry Number	123524-52-7
PubChem CID	65948
Molecular formula	C33H34N4O6
IUPAC name	3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	PV23P19YUG

Computed Descriptors

Molecular Weight	582.6
XLogP3	6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	10
Exact Mass	582.24783482
Monoisotopic Mass	582.24783482
Topological Polar Surface Area	140
Heavy Atom Count	43
Formal Charge	0

Physical & Chemical Properties

Melting Point	193-195
LogP	5.18

Physical description & handling notes

Insoluble in water

GHS Hazard Classification

Reported hazard statements	H302 (100%), H318 (95.1%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H318 (95.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Documented Uses

For the treatment of hypertension.
Oral ingestion of azelnidipine demonstrates rapid and dose-dependent absorption.
In one study, following a single 4mg oral dose of 14C-labeled azelnidipine in humans, about 26% of the drug was thought to br excreted in the urine and 63% in the feces during the 1 week period post administration.
In a Chinese study examining the pharmacokinetics of the drug, the volume of distribution was found to be 1749 +/- 964.
Azelnidipine is widely bound to human plasma proteins (90%–91%).
Like most members of its class, azelnidipine primarily undergoes first-pass hepatic metabolism. Azelnidipine is metabolized by hepatic cytochrome P450 (CYP) 3A4 and has no active metabolite product. It may interact with other drugs or compounds that are substrates for this enzyme. Azelnidipine is lipophilic and has a potent affinity for membranes of vascular smooth muscle cells.

Synonyms

Azelnidipine; 123524-52-7; Calblock; CS-905; DTXSID3020120; Azelnidipino; PV23P19YUG; CS905; DTXCID50120; azelnidipinum; RefChem:560476; Azelnidipine [INN]; CS 905; MFCD00865803; C33H34N4O6; HMS3651D18

Frequently Asked Questions

What are the CAS number and molecular formula of Azelnidipine?

CAS 123524-52-7; molecular formula C33H34N4O6; molecular weight — g/mol.

What other names is Azelnidipine known by?

Azelnidipine, 123524-52-7, Calblock, CS-905, DTXSID3020120, Azelnidipino.

Is Azelnidipine classified as hazardous?

Hazard statements reported: H302, H318.

What are the key physical properties of Azelnidipine?

Melting Point: 193-195; LogP: 5.18.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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