盐酸苯达莫司汀

Description

Bendamustine Hydrochloride · CAS 3543-75-7 · C16H22Cl3N3O2. UNII 981Y8SX18M.

Identification

CAS Registry Number	3543-75-7
PubChem CID	77082
Molecular formula	C16H22Cl3N3O2
IUPAC name	4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydrochloride
UNII (FDA)	981Y8SX18M

Computed Descriptors

Molecular Weight	394.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	393.077760
Monoisotopic Mass	393.077760
Topological Polar Surface Area	58.4
Heavy Atom Count	24
Formal Charge	0
Complexity	380

GHS Hazard Classification

Reported hazard statements	H301 (95.9%), H340 (12.2%), H350 (12.2%), H351 (87.8%), H360 (95.9%)

Documented Uses

• Breast Feeding; Lactation; Antineoplastic Agents, Alkylating; Nitrosourea Compounds
• Bendamustine hydrochloride is approved to treat:
• • B-cell non-Hodgkin lymphoma (NHL) that is indolent (slow-growing) and got worse during or within 6 months after treatment with rituximab.
• • Chronic lymphocytic leukemia (CLL).
• Bendamustine hydrochloride is also being studied in the treatment of other types of cancer.
• A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,

Synonyms

Bendamustine hydrochloride; 3543-75-7; Bendamustine HCl; Treanda; Ribomustin; Bendamustin hydrochloride; Bendeka; Ribomustine; SyB L-0501; VIVIMUSTA; Levact; NSC-138783; SYBL-0501; 981Y8SX18M; DTXSID40188912; NSC138783

Frequently Asked Questions

What are the CAS number and molecular formula of Bendamustine Hydrochloride?

CAS 3543-75-7; molecular formula C16H22Cl3N3O2; molecular weight — g/mol.

What other names is Bendamustine Hydrochloride known by?

Bendamustine hydrochloride, 3543-75-7, Bendamustine HCl, Treanda, Ribomustin, Bendamustin hydrochloride.

Is Bendamustine Hydrochloride classified as hazardous?

Hazard statements reported: H301, H340, H350, H351, H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.