苯氟米醇

Description

Benflumetol · CAS 82186-77-4 · C30H32Cl3NO. UNII F38R0JR742.

Identification

CAS Registry Number	82186-77-4
PubChem CID	6437380
Molecular formula	C30H32Cl3NO
IUPAC name	2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
UNII (FDA)	F38R0JR742

Computed Descriptors

Molecular Weight	528.9
XLogP3	8.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	10
Exact Mass	527.154948
Monoisotopic Mass	527.154948
Topological Polar Surface Area	23.5
Heavy Atom Count	35
Formal Charge	0

Physical description & handling notes

• Solid
• Yellow powder
• Odorless

Regulatory Status

GHS notification summary	50% (1 / 2)

GHS Hazard Classification

GHS notification summary	50% (1 / 2)
Reported hazard statements	H315 (50%), H319 (50%), H335 (50%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Lumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
• For more Therapeutic Uses (Complete) data for BENFLUMETOL (6 total), please visit the HSDB record page.
• Take with food. Food increases absorption.
• Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

Synonyms

Lumefantrine; Benflumetol; 82186-77-4; benflumelol; DTXSID3046663; GNF-Pf-1971; Lumefantrina; Lumefantrinum; 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol; F38R0JR742; (+-)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-alpha-((dibutylamino)methyl)fluorene-4-methanol; CPG-56695; DTXCID1026663; CHEBI:156095; COARTEM COMPONENT LUMEFANTRINE; 9H-Fluorene-4-methanol, 2,7-dichloro-9-((4-chlorophenyl)methylene)-alpha-((dibutylamino)methyl)-, (Z)-

Frequently Asked Questions

What are the CAS number and molecular formula of Benflumetol?

CAS 82186-77-4; molecular formula C30H32Cl3NO; molecular weight — g/mol.

What other names is Benflumetol known by?

Lumefantrine, Benflumetol, 82186-77-4, benflumelol, DTXSID3046663, GNF-Pf-1971.

Is Benflumetol classified as hazardous?

50% of GHS notifications report no hazard classification (1 of 2).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.