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Description

benzhexol hydrochloride · CAS 52-49-3 · C20H32ClNO. UNII AO61G82577.

Identification

CAS Registry Number	52-49-3
PubChem CID	66007
Molecular formula	C20H32ClNO
IUPAC name	1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
UNII (FDA)	AO61G82577

Computed Descriptors

Molecular Weight	337.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	337.2172423
Monoisotopic Mass	337.2172423
Topological Polar Surface Area	23.5
Heavy Atom Count	23
Formal Charge	0
Complexity	314

Physical description & handling notes

• >50.7 [ug/mL] (The mean of the results at pH 7.4)
• 174.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H301 (20%), H312 (20%), H315 (20%), H317 (20%), H319 (20%), H332 (20%), H335 (20%)

Documented Uses

• Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
• Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
• Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.

Synonyms

Trihexyphenidyl hydrochloride; 52-49-3; Trihexyphenidyl HCl; Cyclodol; Parcopane; Romparkin; Cyclodolum; Tremin; Aparkane; Triphedinon; Sedrina; DTXSID8045802; NSC-757357; AO61G82577; Trihexyphenidyli hydrochloridum; DTXCID6025802

Frequently Asked Questions

What are the CAS number and molecular formula of benzhexol hydrochloride?

CAS 52-49-3; molecular formula C20H32ClNO; molecular weight — g/mol.

What other names is benzhexol hydrochloride known by?

Trihexyphenidyl hydrochloride, 52-49-3, Trihexyphenidyl HCl, Cyclodol, Parcopane, Romparkin.

Is benzhexol hydrochloride classified as hazardous?

Hazard statements reported: H302, H301, H312, H315, H317.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.