比马前列素

Description

Bimatoprost · CAS 155206-00-1 · C25H37NO4. UNII QXS94885MZ. Boiling Point: 629.8; Melting Point: 63-67; Solubility: 1.87e-02 g/L.

Identification

CAS Registry Number	155206-00-1
PubChem CID	5311027
Molecular formula	C25H37NO4
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
UNII (FDA)	QXS94885MZ

Computed Descriptors

Molecular Weight	415.6
XLogP3	2.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	12
Exact Mass	415.27225866
Monoisotopic Mass	415.27225866
Topological Polar Surface Area	89.8
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Boiling Point	629.8
Melting Point	63-67
Solubility	1.87e-02 g/L
LogP	3.2
Dissociation Constants	14.3, - 0.23

Physical description & handling notes

• Solid
• soluble in water

GHS Hazard Classification

Reported hazard statements	H302 (23.8%), H312 (47.6%), H319 (66.7%), H340 (52.4%), H360 (66.7%), H361 (23.8%)

Documented Uses

• Bimatoprost is used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. These patients must be intolerant to other intraocular pressure lowering medications or inadequately responsive to other treatments. Bimatoprost is also indicated to treat eyelash hypotrichosis.
• Breast Feeding; Lactation; Milk, Human; Antiglaucoma Agents; Prostaglandins
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Established Pharmacologic Class [EPC] - Prostaglandin Analog
• Chemical Structure [CS] - Prostaglandins
• Bimatoprost is a Prostaglandin Analog.

Synonyms

Bimatoprost; 155206-00-1; Lumigan; Latisse; AGN 192024; Prostamide; AGN-192024; bimatoprostum; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide; DURYSTA; QXS94885MZ; CHEBI:51230; DTXSID30895042; GANFORT COMPONENT BIMATOPROST; AGN192024; (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E,3S)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethylhept-5-enamide

Frequently Asked Questions

What are the CAS number and molecular formula of Bimatoprost?

CAS 155206-00-1; molecular formula C25H37NO4; molecular weight — g/mol.

What other names is Bimatoprost known by?

Bimatoprost, 155206-00-1, Lumigan, Latisse, AGN 192024, Prostamide.

Is Bimatoprost classified as hazardous?

Hazard statements reported: H302, H312, H319, H340, H360.

What are the key physical properties of Bimatoprost?

Boiling Point: 629.8; Melting Point: 63-67; Solubility: 1.87e-02 g/L; LogP: 3.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.