Calcium folinatc

Description

Calcium folinatc · CAS 1492-18-8 · C20H21CaN7O7. UNII RPR1R4C0P4. Solubility: DMSO « 1 (mg/mL); Solubility: H2O 100 (mg/mL); Solubility: 0.1 N NaOH < 20 (mg/mL).

Identification

CAS Registry Number	1492-18-8
PubChem CID	135403647
Molecular formula	C20H21CaN7O7
IUPAC name	calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
UNII (FDA)	RPR1R4C0P4

Computed Descriptors

Molecular Weight	511.5
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	511.1128369
Monoisotopic Mass	511.1128369
Topological Polar Surface Area	221
Heavy Atom Count	35
Formal Charge	0
Complexity	900

Physical & Chemical Properties

Solubility	DMSO « 1 (mg/mL)
Solubility	H2O 100 (mg/mL)
Solubility	0.1 N NaOH < 20 (mg/mL)
Optical Rotation	(c = 1, H2O) [a]20 D = 13.0 ± 2º

Physical description & handling notes

• Bulk: Calcium leucovorin was stable in bulk form after 4 weeks storage at 60 ° C (HPLC). Solution: Leucovorin in 0.1 N NaOH (pH 13) and in deionized water (pH6) was stable at room temperature under laboratory illumination for at least 24 hours (HPLC).
• 198.8 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
• 202.35 Ų [M-H]- [CCS Type: DT; Method: stepped-field]

GHS Hazard Classification

Reported hazard statements	H315 (100%), H317 (100%), H319 (100%), H334 (100%), H335 (100%)

Documented Uses

• For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate.
• Breast Feeding; Lactation; Milk, Human; Antidotes; Vitamin B Complex; Vitamins
• Leucovorin calcium is approved to be used alone or with other drugs to treat:
• • Colorectal cancer. It is used with fluorouracil as palliative treatment in patients with advanced disease.
• • Anemia. It is used to treat megaloblastic anemia that occurs when the body does not get enough of a vitamin called folic acid. It is used by patients who cannot take the vitamin by mouth.
• Leucovorin calcium is also used to prevent and treat the toxic effects of high-dosemethotrexate when used to treat osteosarcoma and other types of cancer. It is also used to treat overdoses of methotrexate or other folic acid antagonists. The drug is also being studied in the treatment of other conditions and types of cancer.

Synonyms

LEUCOVORIN CALCIUM; Calcium leucovorin; Calcii folinas; Folaren; Folidan; Rescuvolin; folinate calcium; Anhydrous calcium folinate; Leucovorin calcium preservative free; Calcifolin; Lederfolat; Calinat; Folinac; RPR1R4C0P4; NSC-3590; Leucovorin calcium [USP]

Frequently Asked Questions

What are the CAS number and molecular formula of Calcium folinatc?

CAS 1492-18-8; molecular formula C20H21CaN7O7; molecular weight — g/mol.

What other names is Calcium folinatc known by?

LEUCOVORIN CALCIUM, Calcium leucovorin, Calcii folinas, Folaren, Folidan, Rescuvolin.

Is Calcium folinatc classified as hazardous?

Hazard statements reported: H315, H317, H319, H334, H335.

What are the key physical properties of Calcium folinatc?

Solubility: DMSO « 1 (mg/mL); Solubility: H2O 100 (mg/mL); Solubility: 0.1 N NaOH < 20 (mg/mL); Optical Rotation: (c = 1, H2O) [a]20 D = 13.0 ± 2º.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.