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Home › Product Catalog › Canagliflozin hemihydrate

Canagliflozin hemihydrate

CAS 928672-86-0C24H25FO5SMW 444.5

Canagliflozin hemihydrate (CAS No. 928672-86-0) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number928672-86-0
Molecular FormulaC24H25FO5S
Molecular Weight444.5
Melting Point68-72
Boiling Point‎642.9±55.0
LogP3.44
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Canagliflozin hemihydrate?

The CAS number of Canagliflozin hemihydrate is 928672-86-0.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Canagliflozin hemihydrate?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Canagliflozin hemihydrate or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Canagliflozin hemihydrate · CAS 928672-86-0 · C24H25FO5S. UNII 6S49DGR869. Boiling Point: ‎642.9±55.0; Melting Point: 68-72; LogP: 3.44.

Identification

CAS Registry Number928672-86-0
PubChem CID24812758
Molecular formulaC24H25FO5S
IUPAC name(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
UNII (FDA)6S49DGR869

Computed Descriptors

Molecular Weight444.5
XLogP33.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass444.14067323
Monoisotopic Mass444.14067323
Topological Polar Surface Area118
Heavy Atom Count31
Formal Charge0

Physical & Chemical Properties

Boiling Point‎642.9±55.0
Melting Point68-72
LogP3.44
Dissociation Constants13.34

Physical description & handling notes

  • almost insoluble
  • Practically insoluble in aqueous media from pH 1.1 to pH 12.9 /Canagliflozin hemihydrate/
  • log Kow: 1.59; Koc: 5.9 /Canagliflozin hemihydrate (928672-86-0)/
  • Table: Canagliflozin Preparations [Table#8277]

GHS Hazard Classification

Reported hazard statementsH302 (66.7%), H318 (16.7%), H319 (50%), H361 (66.7%), H362 (33.3%), H411 (83.3%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H318 (16.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Documented Uses

  • Invokamet is canagliflozin hemihydrate in combination with metformin hydrochloride. /Canagliflozin hemihydrate (928672-86-0)/
  • Canagliflozin, approved by the Food and Drug Administration (FDA) in 2013, belongs to a class of medications known as sodium-glucose cotransporter 2 (SGLT2) inhibitors.
  • Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Sodium-Glucose Cotransporter 2 Inhibitors; SGLT2 Inhibitors
  • Canagliflozin; METformin Hydrochloride
  • Invokana (canagliflozin) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. /Included in US product label/
  • Hypersensitivity reactions (e.g., generalized urticaria), some serious, have been reported with canagliflozin treatment. These reactions generally occurred within hours to days of canagliflozin initiation. If a hypersensitivity reaction occurs, the drug should be discontinued, appropriate treatment instituted, and the patient monitored until signs and symptoms resolve.

Synonyms

Canagliflozin; 842133-18-0; Invokana; Canagliflozin anhydrous; TA-7284; JNJ-28431754; 6S49DGR869; 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene; CHEBI:73274; DTXSID601004469; Canagliflozina; Canagliflozine; (1S)-1,5-Anhydro-1-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-D-glucitol; (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol; (1S)-1,5-Anhydro-1-c-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-D-glucitol; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-

Frequently Asked Questions

What are the CAS number and molecular formula of Canagliflozin hemihydrate?

CAS 928672-86-0; molecular formula C24H25FO5S; molecular weight — g/mol.

What other names is Canagliflozin hemihydrate known by?

Canagliflozin, 842133-18-0, Invokana, Canagliflozin anhydrous, TA-7284, JNJ-28431754.

Is Canagliflozin hemihydrate classified as hazardous?

Hazard statements reported: H302, H318, H319, H361, H362.

What are the key physical properties of Canagliflozin hemihydrate?

Boiling Point: ‎642.9±55.0; Melting Point: 68-72; LogP: 3.44; Dissociation Constants: 13.34.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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