carmustine

Description

carmustine · CAS 154-93-8 · C5H9Cl2N3O2. UNII U68WG3173Y. Melting Point: 86 to 90 °F (NTP, 1992); Melting Point: 31; Melting Point: 31 °C.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• 1,3-bis(2-chloroethyl)-1-nitrosourea is an orange-yellow solid. (NTP, 1992)
• Solid
• Light yellow powder
• Light yellow powder that melts to an oily liquid
• less than 1 mg/mL at 64 °F (NTP, 1992)
• Very soluble in ethanol

GHS Hazard Classification

Documented Uses

• Medication to treat cancer of the lymph system, cancerous brain tumors, and a certain type of bone marrow cancer
• THERAPEUTIC CATEGORY: Antineoplastic
• For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
• /Carmustine/ may be synthesized by nitrosation with sodium nitrite of the appropriate substituted uera - in this case 1,3-bis(2-chloroethyl)urea - in a cold, acid medium (e.g., formic acid).
• ... designed to deliver carmustine directly into the surgical cavity created when a brain tumor is resected /Gliadel wafer/
• Carmustine (BCNU) is a parenterally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several forms of cancer including leukemias, lymphomas, and breast, testicular, ovarian, gastric and pancreatic cancer. Carmustine therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.

Synonyms

carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; BiCNU; Becenun; Bischloroethyl nitrosourea; Carmustina; Carmustinum; Bischlorethylnitrosurea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bischlorethylnitrosourea; Becenum

Frequently Asked Questions

What are the CAS number and molecular formula of carmustine?

CAS 154-93-8; molecular formula C5H9Cl2N3O2; molecular weight — g/mol.

What other names is carmustine known by?

carmustine, 154-93-8, 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU, Carmustin, Nitrumon.

Is carmustine classified as hazardous?

Hazard statements reported: H300, H350, H360, H341, H370.

What are the key physical properties of carmustine?

Melting Point: 86 to 90 °F (NTP, 1992); Melting Point: 31; Melting Point: 31 °C; Solubility: 4000.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.