二醋酸西曲瑞克

Description

Cetrorelix diacetate · CAS 130143-01-0 · C70H92ClN17O14. UNII OON1HFZ4BA. Solubility: 6.94e-03 g/L.

Identification

CAS Registry Number	130143-01-0
PubChem CID	25074887
Molecular formula	C70H92ClN17O14
UNII (FDA)	OON1HFZ4BA

Computed Descriptors

Molecular Weight	1431.0
XLogP3	1.9
Hydrogen Bond Donor Count	16
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	38
Exact Mass	1429.6698184
Monoisotopic Mass	1429.6698184
Topological Polar Surface Area	498
Heavy Atom Count	102
Formal Charge	0

Physical & Chemical Properties

Solubility	6.94e-03 g/L

Physical description & handling notes

• Solid
• Soluble in water /Acetate/

GHS Hazard Classification

Reported hazard statements	H360 (100%), H319 (100%)

Documented Uses

• Cetrorelix is manufactured exclusively by classical fragment condensation on a kilogram scale. Two synthesis strategies proceed via either the N-terminal tripeptide (D-Nal1-D-Cpa2-D-Pal3) or the C-terminal tripeptide (Arg8-Pro9-D-Ala10)PEER REVIEWED**
• Preparation: A.V. Schally, S. Bajusz, EP 299402 (1989 to Asta); eidem, US 4800191 (1989)
• Cetrotide (cetrorelix acetate for injection) is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian stimulation. /Acetate/
• Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur.
• For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
• Cetrorelix is indicated for the inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation.

Synonyms

Cetrorelix; 120287-85-6; Cetrorelixum; OON1HFZ4BA; SB-75; DTXSID7040996; CHEBI:59224; RefChem:58062; DTXCID5020996; H01CC02; LHRH, N-Ac-1-Nal(2)-2-Phe(pCl)-3-Pal(3)-6-Cit-10-Ala-; Cetrotide; Cetrorelixum [INN-Latin]; Cetrorelix (INN); Cetrorelix [INN]; SB 75

Frequently Asked Questions

What are the CAS number and molecular formula of Cetrorelix diacetate?

CAS 130143-01-0; molecular formula C70H92ClN17O14; molecular weight — g/mol.

What other names is Cetrorelix diacetate known by?

Cetrorelix, 120287-85-6, Cetrorelixum, OON1HFZ4BA, SB-75, DTXSID7040996.

Is Cetrorelix diacetate classified as hazardous?

Hazard statements reported: H360, H319.

What are the key physical properties of Cetrorelix diacetate?

Solubility: 6.94e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.