马来酸氯苯那敏

Description

CHLORPHENIRAMINE MALEATE · CAS 113-92-8 · C16H19ClN2. UNII 3U6IO1965U. Boiling Point: 142; Boiling Point: 142 °C @ 1.0 MM HG; Melting Point: 130 - 135 °C.

Identification

CAS Registry Number	113-92-8
PubChem CID	2725
Molecular formula	C16H19ClN2
IUPAC name	3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
UNII (FDA)	3U6IO1965U

Computed Descriptors

Molecular Weight	274.79
XLogP3	3.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	274.1236763
Monoisotopic Mass	274.1236763
Topological Polar Surface Area	16.1
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Boiling Point	142
Boiling Point	142 °C @ 1.0 MM HG
Melting Point	130 - 135 °C
Solubility	5500
Solubility	160.0 mg/mL at 25 °C
LogP	3.38
LogP	3.66
Dissociation Constants	9.26
Dissociation Constants	9.13 (at 25 °C)

Physical description & handling notes

• Solid
• OILY LIQUID
• UV max absorption (water): 261 nm (E=5760), Solubility in mg/ml at 25 °C: Ethanol 330; chloroform 240; water 160; methanol 130; pH of a 2% aqueous solution about 5 /Maleate/
• SENSITIVE TO LIGHT. /MALEATE/
• BOX LIKE PRISMS & IRREGULAR FRAGMENTS; INDEX OF REFRACTION: 1.533 (ALPHA); 1.668 (BETA; INTERMEDIATE INDEX); LESS THAN 1.734 (GAMMA; INCLINED) /MALEATE/
• 164.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4020321]

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.00279
• Used used in the prevention of the symptoms of allergic conditions such as rhinitis, urticaria, allergy, common cold, asthma and hay fever.
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• CONDENSATION OF 2-(P-CHLORO-ALPHA-(2-CHLOROETHYL)BENZYL)PYRIDINE WITH DIMETHYLAMINE IN THE PRESENCE OF SODAMIDE

Synonyms

chlorpheniramine; Chlorphenamine; 132-22-9; Chlorophenylpyridamine; Haynon; Clorfeniramina; Allergican; Allergisan; Clorfenamina; Histadur; Chloropheniramine; Chlorprophenpyridamine; Chloroprophenpyridamine; Chlorpheniraminum; Chlorphenaminum; 4-Chloropheniramine

Frequently Asked Questions

What are the CAS number and molecular formula of CHLORPHENIRAMINE MALEATE?

CAS 113-92-8; molecular formula C16H19ClN2; molecular weight — g/mol.

What other names is CHLORPHENIRAMINE MALEATE known by?

chlorpheniramine, Chlorphenamine, 132-22-9, Chlorophenylpyridamine, Haynon, Clorfeniramina.

What are the key physical properties of CHLORPHENIRAMINE MALEATE?

Boiling Point: 142; Boiling Point: 142 °C @ 1.0 MM HG; Melting Point: 130 - 135 °C; Solubility: 5500.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.