ciclopirox olamine

Description

ciclopirox olamine · CAS 41621-49-2 · C14H24N2O3. UNII 50MD4SB4AP.

Identification

CAS Registry Number	41621-49-2
PubChem CID	38911
Molecular formula	C14H24N2O3
IUPAC name	2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
UNII (FDA)	50MD4SB4AP

Computed Descriptors

Molecular Weight	268.35
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	268.17869263
Monoisotopic Mass	268.17869263
Topological Polar Surface Area	86.8
Heavy Atom Count	19
Formal Charge	0
Complexity	335

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Antidandruff; Antimicrobial
GHS notification summary	0.9% (1 / 112)

GHS Hazard Classification

GHS notification summary	0.9% (1 / 112)
Reported hazard statements	H315 (43.8%), H317 (10.7%), H319 (42.9%), H335 (42%), H400 (56.2%)

Documented Uses

• Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to <i>Trichophyton rubrum</i>.
• Cosmetics -> Antidandruff; Antimicrobial
• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
• Decreased Protein Synthesis [PE]; Decreased RNA Replication [PE]; Decreased DNA Replication [PE]; Protein Synthesis Inhibitors [MoA]
• Glucuronidation is the main metabolic pathway of ciclopirox. Route of Elimination: Most of the compound is excreted either unchanged or as glucuronide. After oral administration of 10 mg of radiolabeled drug (14C-ciclopirox) to healthy volunteers, approximately 96% of the radioactivity was excreted renally within 12 hours of administration. Ninety-four percent of the renally excreted radioactivity was in the form of glucuronides. Half Life: 1.7 hours for 1% topical solution.

Synonyms

Ciclopirox olamine; 41621-49-2; Batrafen; Micoxolamina; Brumixol; Mycoster; Ciclochem; Dafnegin; HOE 296; Ciclopirox ethanolamine salt (1:1); DTXSID6045583; HOE-296; 50MD4SB4AP; NSC-336278; DTXCID4025583; cyclopyroxolamine

Frequently Asked Questions

What are the CAS number and molecular formula of ciclopirox olamine?

CAS 41621-49-2; molecular formula C14H24N2O3; molecular weight — g/mol.

What other names is ciclopirox olamine known by?

Ciclopirox olamine, 41621-49-2, Batrafen, Micoxolamina, Brumixol, Mycoster.

What is the regulatory status of ciclopirox olamine?

Documented regulatory listings: CIR / INCI: Antidandruff; Antimicrobial.

Is ciclopirox olamine classified as hazardous?

0.9% of GHS notifications report no hazard classification (1 of 112).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.