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Cyclopamine

CAS 4449-51-8C27H41NO2MW 411.6

Cyclopamine (CAS No. 4449-51-8) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number4449-51-8
Molecular FormulaC27H41NO2
Molecular Weight411.6
LogP3.5
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Cyclopamine?

The CAS number of Cyclopamine is 4449-51-8.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Cyclopamine?

Main applications include Organic Chemicals.

How do I buy Cyclopamine or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Cyclopamine · CAS 4449-51-8 · C27H41NO2. UNII ZH658AJ192.

Identification

CAS Registry Number4449-51-8
PubChem CID442972
Molecular formulaC27H41NO2
IUPAC name(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
UNII (FDA)ZH658AJ192

Computed Descriptors

Molecular Weight411.6
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass411.313729551
Monoisotopic Mass411.313729551
Topological Polar Surface Area41.5
Heavy Atom Count30
Formal Charge0

Physical description & handling notes

  • 218.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID6043709]
  • 219.1 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6043709]

GHS Hazard Classification

Reported hazard statementsH341 (88.6%), H361 (90.9%)

H341 (88.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H361 (90.9%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Documented Uses

  • It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
  • 11-Deoxojervine is a precursor for the biosynthesis of jervine in Veratrum grandiflorum.
  • Plants have and continue to provide medicine with an abundance of pharmacologically interesting and useful chemicals. In recent years, cyclopamine, a steroidal alkaloid isolated from Veratrum californicum, has been instrumental in dissecting the sonic hedgehog pathway. This brief report outlines cyclopamine's discovery with discussion of its potential application to clinical dermatology.
  • 3 OR 4. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB). /VERATRUM VIRIDE ALKALOIDS/
  • Conversion to teratogen of cyclopamine by rumen microorganisms is not essential. Indeed, ruminant sheep and non-ruminant rabbits were about equally susceptible to cyclopamine on a body weight basis.

Synonyms

CYCLOPAMINE; 4449-51-8; 11-Deoxojervine; 11-Deoxyjervine; DTXSID6043709; Alkaloid V; ZH658AJ192; NSC-734950; DTXCID4023709; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; (3beta23R)-17,23-Epoxyveratraman-3-ol; 3,4'-Dinitroflavone; RefChem:129819; 628-058-8; MFCD09878269; Jervine, 11-deoxo-

Frequently Asked Questions

What are the CAS number and molecular formula of Cyclopamine?

CAS 4449-51-8; molecular formula C27H41NO2; molecular weight — g/mol.

What other names is Cyclopamine known by?

CYCLOPAMINE, 4449-51-8, 11-Deoxojervine, 11-Deoxyjervine, DTXSID6043709, Alkaloid V.

Is Cyclopamine classified as hazardous?

Hazard statements reported: H341, H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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