环磷酰胺一水合物

Description

Cyclophosphamide monohydrate · CAS 6055-19-2 · C7H15Cl2N2O2P. UNII 6UXW23996M. Boiling Point: 336 °C; Melting Point: 106 to 113 °F (NTP, 1992); Melting Point: 48-49.

Identification

CAS Registry Number	6055-19-2
PubChem CID	2907
Molecular formula	C7H15Cl2N2O2P
IUPAC name	N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
UNII (FDA)	6UXW23996M

Computed Descriptors

Molecular Weight	261.08
XLogP3	0.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	260.0248201
Monoisotopic Mass	260.0248201
Topological Polar Surface Area	41.6
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Boiling Point	336 °C
Melting Point	106 to 113 °F (NTP, 1992)
Melting Point	48-49
Melting Point	49.5-53 °C
Melting Point	41 - 45 °C
Melting Point	49.5 - 53 °C
Flash Point	113 °C c.c.
Solubility	10 to 50 mg/mL at 73 °F (NTP, 1992)
Solubility	Soluble. 1-5 g/100 mL at 23 °C
Solubility	In water, 40,000 ppm @ 20 °C

Physical description & handling notes

• Cyclophosphamide is a fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45 °C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.
• White odorless solid; Liquefies upon loss of crystallization water; Darkens on light exposure; [ICSC] White odorless crystalline solid; [MSDSonline]
• Solid
• FINE WHITE CRYSTALLINE POWDER.
• LIQUEFIES ON LOSS OF ITS WATER OF CRYSTALLIZATION
• Crystalline solid

GHS Hazard Classification

Reported hazard statements	H301 (63.2%), H302 (35.3%), H318 (36.8%), H340 (95.6%), H350 (98.5%), H360 (94.1%), H372 (36.8%), H362

Documented Uses

• Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug; [Merck Index] An alkylating agent; [HSDB]
• Antineoplastic for treatment of leukemia, etc; tested for use in chemical shearing of sheep and as an insect chemosterilant.
• Use (kg) in Switzerland (2009): >25
• Use (kg; approx.) in Germany (2009): >250
• Use (kg; exact) in Germany (2009): 252
• Consumption (g per capita) in Switzerland (2009): 0.0032

Synonyms

cyclophosphamide; 50-18-0; Cytoxan; Cyclophosphamid; Cyclophosphane; Clafen; Endoxan; Cyclophosphan; Cytophosphan; Procytox; Sendoxan; Cyclophosphamidum; Claphene; Cyclostin; Endoxana; Endoxanal

Frequently Asked Questions

What are the CAS number and molecular formula of Cyclophosphamide monohydrate?

CAS 6055-19-2; molecular formula C7H15Cl2N2O2P; molecular weight — g/mol.

What other names is Cyclophosphamide monohydrate known by?

cyclophosphamide, 50-18-0, Cytoxan, Cyclophosphamid, Cyclophosphane, Clafen.

Is Cyclophosphamide monohydrate classified as hazardous?

Hazard statements reported: H301, H302, H318, H340, H350.

What are the key physical properties of Cyclophosphamide monohydrate?

Boiling Point: 336 °C; Melting Point: 106 to 113 °F (NTP, 1992); Melting Point: 48-49; Melting Point: 49.5-53 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.