Cyproterone acetate

Description

Cyproterone · CAS 427-51-0 · C24H29ClO4. UNII 4KM2BN5JHF. Melting Point: 200-201; Melting Point: 200-201 °C.

Identification

CAS Registry Number	427-51-0
PubChem CID	9880
Molecular formula	C24H29ClO4
IUPAC name	[(1S,2S,3S,5R,11R,12S,15R,16S)-15-acetyl-9-chloro-2,16-dimethyl-6-oxo-15-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dienyl] acetate
UNII (FDA)	4KM2BN5JHF

Computed Descriptors

Molecular Weight	416.9
XLogP3	3.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	416.1754371
Monoisotopic Mass	416.1754371
Topological Polar Surface Area	60.4
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Melting Point	200-201
Melting Point	200-201 °C

Physical description & handling notes

• Crystals from diisopropyl ether
• White crystalline powder
• Very soluble in dichloromethane and acetone; soluble in methanol; sparingly soluble in ethanol.
• Stable under recommended storage conditions.
• Specific rotation = +152 deg to +157 deg at 20 °C
• When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

GHS Hazard Classification

Reported hazard statements	H312 (64.3%), H332 (64.3%), H351 (97.1%), H360 (32.9%), H373 (27.1%)

Documented Uses

• For the palliative treatment of patients with advanced prostatic carcinoma.
• Reported impurities include: 3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-trien-17-yl acetate and 6-methoxy-3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]-pregna-1,4,6-trien-17-yl acetate.
• Androgen Antagonists; Antineoplastic Agents; Contraceptive Agents, Male; Progestational Hormones, Synthetic
• /Cyproterone is indicated for the/ control of libido in severe hypersexuality and/or sexual deviation in the adult male.
• /Cyproterone is indicated for the/ management of patients with prostatic cancer (1) to suppress "flare" with initial LHRH analogue therapy,(2) in long-term palliative treatment where LHRH analogues or surgery are contraindicated, not tolerated, or where oral therapy is preferred, and (3) in the treatment of hot flushes in patients under treatment with LHRH analogues or who have had orchidectomy.
• Dianette (cyproterone acetate/ethinylestradiol) is recommended for use in women only for the treatment of (a) severe acne, refractory to prolonged oral antibiotic therapy; (b) moderately severe hirsutism.

Synonyms

CYPROTERONE ACETATE; 427-51-0; Androcur; Cyproterone 17-O-acetate; Cyprostat; NSC-81430; SH 714; SH-714; Cyproterone 17alpha-acetate; DTXSID5020366; 4KM2BN5JHF; SH714; NSC81430; 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-; DTXCID30366; CHEBI:50743

Frequently Asked Questions

What are the CAS number and molecular formula of Cyproterone?

CAS 427-51-0; molecular formula C24H29ClO4; molecular weight — g/mol.

What other names is Cyproterone known by?

CYPROTERONE ACETATE, 427-51-0, Androcur, Cyproterone 17-O-acetate, Cyprostat, NSC-81430.

Is Cyproterone classified as hazardous?

Hazard statements reported: H312, H332, H351, H360, H373.

What are the key physical properties of Cyproterone?

Melting Point: 200-201; Melting Point: 200-201 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.