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dacomitinib

CAS 1110813-31-4C24H25ClFN5O2MW 469.9

dacomitinib (CAS No. 1110813-31-4) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1110813-31-4
Molecular FormulaC24H25ClFN5O2
Molecular Weight469.9
Melting Point184-187 ºC
Boiling Point665.7
LogP3.92
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of dacomitinib?

The CAS number of dacomitinib is 1110813-31-4.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of dacomitinib?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy dacomitinib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

dacomitinib · CAS 1110813-31-4 · C24H25ClFN5O2. UNII 2XJX250C20. Boiling Point: 665.7; Melting Point: 184-187 ºC; Solubility: <1 mg/mL.

Identification

CAS Registry Number1110813-31-4
PubChem CID11511120
Molecular formulaC24H25ClFN5O2
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
UNII (FDA)2XJX250C20

Computed Descriptors

Molecular Weight469.9
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass469.1680809
Monoisotopic Mass469.1680809
Topological Polar Surface Area79.4
Heavy Atom Count33
Formal Charge0

Physical & Chemical Properties

Boiling Point665.7
Melting Point184-187 ºC
Solubility<1 mg/mL
LogP3.92

Documented Uses

  • Dacomitinib is a multi-kinase receptor inhibitor used in the therapy of cases of non-small cell lung cancer that harbor activating mutations in the epidermal growth factor receptor gene (EGFR). Dacomitinib is associated with high rate of transient serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Tyrosine Kinase Inhibitors
  • Dacomitinib is approved to treat:
  • • Non-small cell lung cancer (NSCLC) that has metastasized (spread to other parts of the body). It is used as first-line treatment in patients whose tumors have certain EGFRgenemutations.
  • Dacomitinib is also being studied in the treatment of other types of cancer.
  • Avoid grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of dacomitinib.

Synonyms

Dacomitinib; 1110813-31-4; PF-00299804; Dacomitinib anhydrous; dacomitinibum; Vizimpro; PF-299804; 2XJX250C20; pf00299804; PF 00299804-03; PF-00299804-03; (2e)-N-{4-[(3-Chloro-4-Fluorophenyl)amino]-7-Methoxyquinazolin-6-Yl}-4-(Piperidin-1-Yl)but-2-Enamide; CHEBI:132268; DTXSID50149493; (2E)-N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-METHOXYQUINAZOLIN-6-YL)-4-PIPERIDIN-1-YLBUT-2-ENAMIDE; 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxy-6-quinazolinyl)-4-(1-piperidinyl)-, (2E)-

Frequently Asked Questions

What are the CAS number and molecular formula of dacomitinib?

CAS 1110813-31-4; molecular formula C24H25ClFN5O2; molecular weight — g/mol.

What other names is dacomitinib known by?

Dacomitinib, 1110813-31-4, PF-00299804, Dacomitinib anhydrous, dacomitinibum, Vizimpro.

What are the key physical properties of dacomitinib?

Boiling Point: 665.7; Melting Point: 184-187 ºC; Solubility: <1 mg/mL; LogP: 3.92.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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