Dapiprazole

Description

Dapiprazole · CAS 72822-12-9 · C19H27N5. UNII 5RNZ8GJO7K. Solubility: 7.51e-01 g/L; LogP: 2.3.

Identification

CAS Registry Number	72822-12-9
PubChem CID	3033538
Molecular formula	C19H27N5
IUPAC name	3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine
UNII (FDA)	5RNZ8GJO7K

Computed Descriptors

Molecular Weight	325.5
XLogP3	2.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	325.22664588
Monoisotopic Mass	325.22664588
Topological Polar Surface Area	37.2
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Solubility	7.51e-01 g/L
LogP	2.3

Physical description & handling notes

• Solid
• Soluble

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%)

Documented Uses

• Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations.
• Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
• Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
• Mechanisms of Action [MoA] - Adrenergic alpha-Antagonists
• Established Pharmacologic Class [EPC] - alpha-Adrenergic Blocker
• Dapiprazole is an alpha-Adrenergic Blocker. The mechanism of action of dapiprazole is as an Adrenergic alpha-Antagonist.

Synonyms

Dapiprazole; 72822-12-9; Dapiprazol; dapiprazolum; 5RNZ8GJO7K; 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine; CHEBI:51066; DTXSID90223140; 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine; 1,2,4-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-; dapiprazolo; 1-(2-methylphenyl)-4-(2-(5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyridin-3-yl)ethyl)piperazine; RefChem:57621; DTXCID90145631; S01EX02; Dapiprazole [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Dapiprazole?

CAS 72822-12-9; molecular formula C19H27N5; molecular weight — g/mol.

What other names is Dapiprazole known by?

Dapiprazole, 72822-12-9, Dapiprazol, dapiprazolum, 5RNZ8GJO7K, 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine.

Is Dapiprazole classified as hazardous?

Hazard statements reported: H315, H319.

What are the key physical properties of Dapiprazole?

Solubility: 7.51e-01 g/L; LogP: 2.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.