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Darolutamide

CAS 1297538-32-9C19H19ClN6O2MW 398.8

Darolutamide (CAS No. 1297538-32-9) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1297538-32-9
Molecular FormulaC19H19ClN6O2
Molecular Weight398.8
Boiling Point719.5±60.0
LogP1.904
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Darolutamide?

The CAS number of Darolutamide is 1297538-32-9.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Darolutamide?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Darolutamide or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Darolutamide · CAS 1297538-32-9 · C19H19ClN6O2. UNII X05U0N2RCO. Boiling Point: 719.5±60.0; LogP: 1.904; Dissociation Constants: 11.75.

Identification

CAS Registry Number1297538-32-9
PubChem CID67171867
Molecular formulaC19H19ClN6O2
IUPAC nameN-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
UNII (FDA)X05U0N2RCO

Computed Descriptors

Molecular Weight398.8
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass398.1258016
Monoisotopic Mass398.1258016
Topological Polar Surface Area120
Heavy Atom Count28
Formal Charge0

Physical & Chemical Properties

Boiling Point719.5±60.0
LogP1.904
Dissociation Constants11.75

Physical description & handling notes

  • Darolutamide, through its downstream effects on cancer cell growth, treats castrate-resistant prostate cancer. It inhibits cancer cell growth and markedly lowers prostate specific antigen (PSA) levels through potent androgen receptor antagonism.

GHS Hazard Classification

Reported hazard statementsH302 (100%), H400 (100%), H410 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Documented Uses

  • Darolutamide is indicated for the treatment of adults with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-sensitive prostate cancer (mCSPC), either as monotherapy or in combination with docetaxel.
  • Darolutamide is a third generation, oral nonsteroidal antiandrogen used to treat nonmetastatic castration-resistant prostate cancer. Darolutamide is associated with a low rate of serum enzyme elevation during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.
  • Darolutamide is approved to treat:
  • • Prostate cancer. It is used in adults whose cancer:
  • • Has spread to other parts of the body and responds to treatment that lowers testosterone levels. It is used alone or with docetaxel.
  • • Has not spread to other parts of the body and no longer responds to treatment that lowers testosterone levels.

Synonyms

Darolutamide; 1297538-32-9; ODM-201; Nubeqa; BAY1841788; BAY-1841788; darolutamida; X05U0N2RCO; BAY 1841788; N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; DTXSID101027953; darolutamidum; N-((2S)-1-(3-(3-chloro-4-cyanophenyl)pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; Antiandrogen ODM-201; RefChem:58141; L02BB06

Frequently Asked Questions

What are the CAS number and molecular formula of Darolutamide?

CAS 1297538-32-9; molecular formula C19H19ClN6O2; molecular weight — g/mol.

What other names is Darolutamide known by?

Darolutamide, 1297538-32-9, ODM-201, Nubeqa, BAY1841788, BAY-1841788.

Is Darolutamide classified as hazardous?

Hazard statements reported: H302, H400, H410.

What are the key physical properties of Darolutamide?

Boiling Point: 719.5±60.0; LogP: 1.904; Dissociation Constants: 11.75.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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