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Dasatinib monohydrate

CAS 863127-77-9C22H26ClN7O2SMW 488.0

Dasatinib monohydrate (CAS No. 863127-77-9) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number863127-77-9
Molecular FormulaC22H26ClN7O2S
Molecular Weight488.0
Melting Point280-286 °C
LogP1.8
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Dasatinib monohydrate?

The CAS number of Dasatinib monohydrate is 863127-77-9.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Dasatinib monohydrate?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Dasatinib monohydrate or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Dasatinib monohydrate · CAS 863127-77-9 · C22H26ClN7O2S. UNII X78UG0A0RN. Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L.

Identification

CAS Registry Number863127-77-9
PubChem CID3062316
Molecular formulaC22H26ClN7O2S
IUPAC nameN-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
UNII (FDA)X78UG0A0RN

Computed Descriptors

Molecular Weight488.0
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass487.1557220
Monoisotopic Mass487.1557220
Topological Polar Surface Area135
Heavy Atom Count33
Formal Charge0

Physical & Chemical Properties

Melting Point280-286 °C
Melting Point280 - 286 °C
Solubility1.28e-02 g/L
LogP1.8
LogP3.41

Physical description & handling notes

  • Solid

GHS Hazard Classification

Reported hazard statementsH301 (92.5%), H315 (77.5%), H318 (75%), H351 (80%), H360 (12.5%), H361 (80%), H371 (10%), H372 (80%)

H301 (92.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H315 (77.5%): Causes skin irritation [Warning Skin corrosion/irritation]

Documented Uses

  • Use (kg; approx.) in Germany (2009): >10
  • Consumption (g per capita; approx.) in Germany (2009): 0.000122
  • Dasatinib is a selective tyrosine kinase receptor inhibitor that is used in the therapy of chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
  • Oral - Solid: 20 mg tablet; 50 mg tablet; 70 mg tablet; 80 mg tablet; 100 mg tablet; 140 mg tablet
  • Chronic myeloid leukaemia, not elsewhere classified

Synonyms

Dasatinib; 302962-49-8; Sprycel; BMS-354825; Dasatinib anhydrous; BMS354825; Dasatinib (anhydrous); BMS 354825; dasatinibum; anh. dasatinib; anhydrous dasatinib; dasatinib (anh.); DTXSID4040979; BMS Dasatinib; X78UG0A0RN; NSC732517

Frequently Asked Questions

What are the CAS number and molecular formula of Dasatinib monohydrate?

CAS 863127-77-9; molecular formula C22H26ClN7O2S; molecular weight — g/mol.

What other names is Dasatinib monohydrate known by?

Dasatinib, 302962-49-8, Sprycel, BMS-354825, Dasatinib anhydrous, BMS354825.

Is Dasatinib monohydrate classified as hazardous?

Hazard statements reported: H301, H315, H318, H351, H360.

What are the key physical properties of Dasatinib monohydrate?

Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L; LogP: 1.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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