deferoxamine

Description

deferoxamine · CAS 70-51-9 · C25H48N6O8. UNII J06Y7MXW4D. Melting Point: 140; Melting Point: MP: 180-182 °C /N-ACETYL DERIV/; Melting Point: 138 - 140 °C.

Identification

CAS Registry Number	70-51-9
PubChem CID	2973
Molecular formula	C25H48N6O8
IUPAC name	N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide
UNII (FDA)	J06Y7MXW4D

Computed Descriptors

Molecular Weight	560.7
XLogP3	-2.1
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	23
Exact Mass	560.35336251
Monoisotopic Mass	560.35336251
Topological Polar Surface Area	206
Heavy Atom Count	39
Formal Charge	0

Physical & Chemical Properties

Melting Point	140
Melting Point	MP: 180-182 °C /N-ACETYL DERIV/
Melting Point	138 - 140 °C
Solubility	12000
Solubility	9.90e-02 g/L
LogP	-2.2
LogP	-1.52

Physical description & handling notes

• Solid
• MP: 138-140 °C /MONOHYDRATE/; 172-175 °C /HYDROCHLORIDE/; 148-149 °C /METHANESULFONATE/
• RECONSTITUTED SOLN ARE STABLE FOR 2 WK @ ROOM TEMP /MESYLATE/
• 228.86 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 221.34 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 229.33 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (97.1%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• NATURAL PRODUCT FORMING IRON COMPLEXES, ISOLATED FROM STREPTOMYCES PILOSUS, ETTLINGER ET AL, ISOLATION: BICKEL ET AL, HELV CHIM ACTA 43, 2118 (1960). PREPN FROM FERRIOXAMINE B & STRUCTURE: BICKEL ET AL, HELV CHIM ACTA 43, 2129 (1960).
• THE IRON-CHELATING AGENT DESFERROXAMINE INHIBITED BOTH THE BASELINE AND IRON-STIMULATED AUTOXIDATION OF DOPAMINE OR NOREPINEPHRINE. DESFERROXAMINE APPEARS TO BE A USEFUL TOOL THAT MAY BE ADDED TO SOLUTIONS CONTAINING CATECHOLAMINES TO PREVENT THEIR DEGRADATION.
• Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
• Deferoxamine (DFO or DFOA) is FDA approved to treat iron overload, either acute or chronic. The definition of iron overload is serial ferritin levels above 800 to 3000 ng/mL. The FDA has not approved deferoxamine as first-line therapy for hereditary hemochromatosis unless there is a contraindication to phlebotomy. Clinicians can also use deferoxamine as an off-label treatment for aluminum toxicity in chronic kidney disease (CKD) patients.

Synonyms

deferoxamine; 70-51-9; Desferrioxamine B; DESFERRIOXAMINE; Deferrioxamine; Deferoxamine B; Deferrioxamine B; Deferoxamin; Deferoxaminum; Desferin; DFOM; Desferan; Desferex; Desferral; Desferrin; N-Benzoylferrioxamine B

Frequently Asked Questions

What are the CAS number and molecular formula of deferoxamine?

CAS 70-51-9; molecular formula C25H48N6O8; molecular weight — g/mol.

What other names is deferoxamine known by?

deferoxamine, 70-51-9, Desferrioxamine B, DESFERRIOXAMINE, Deferrioxamine, Deferoxamine B.

Is deferoxamine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of deferoxamine?

Melting Point: 140; Melting Point: MP: 180-182 °C /N-ACETYL DERIV/; Melting Point: 138 - 140 °C; Solubility: 12000.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.