desipramine

Name: desipramine
Brand: Jinan Shenghe Chemical Co., Ltd.

CAS 50-47-5C18H22N2MW 266.4

desipramine (CAS No. 50-47-5) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number50-47-5

Molecular FormulaC18H22N2

Molecular Weight266.4

Melting Point214-218 °C

Boiling Point172-174 °C @ 0.02 MM HG

LogP4.9

Purity按批次COA提供(不公开发布)

Packaging按订单/批次确认(不公开发布)

ApplicationsPharmaceutical Intermediates & APIs

CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)

Purity按批次COA提供(不公开发布)

StorageSealed, cool and dry place

Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of desipramine?

The CAS number of desipramine is 50-47-5.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of desipramine?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy desipramine or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

desipramine · CAS 50-47-5 · C18H22N2. UNII TG537D343B. Boiling Point: 172-174 °C @ 0.02 MM HG; Melting Point: 214-218 °C; Melting Point: 214 - 218 °C.

Identification

CAS Registry Number	50-47-5
PubChem CID	2995
Molecular formula	C18H22N2
IUPAC name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
UNII (FDA)	TG537D343B

Computed Descriptors

Molecular Weight	266.4
XLogP3	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	266.178298710
Monoisotopic Mass	266.178298710
Topological Polar Surface Area	15.3
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Boiling Point	172-174 °C @ 0.02 MM HG
Melting Point	214-218 °C
Melting Point	214 - 218 °C
Solubility	58.6
Solubility	In water, 58.6 mg/l @ 24 °C.
Solubility	3.96e-02 g/L
LogP	4.9
LogP	log Kow = 4.90
LogP	3.7
LogP	4.0

Physical description & handling notes

Solid
WHITE CRYSTALLINE POWDER; ODORLESS; BITTER TASTE; MELTS WITHIN 5 DEG RANGE BETWEEN 208-218 °C; 1 G IN CA 4 ML CHLOROFORM, 20 ML WATER, 20 ML ALC; FREELY SOL IN METHANOL; INSOL IN ETHER /HCL/
UNSTABLE AFTER LONG EXPOSURE TO LIGHT, HEAT, & AIR /HYDROGEN CHLORIDE/
When heated to decomposition it emits toxic fumes of nitroxides.
163.5 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: Antidepressants]
160.93 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (66.7%), H336 (66.7%), H370 (66.7%), H400 (33.3%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H336 (66.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

Documented Uses

For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.
FREE BASE & HYDROCHLORIDE: BRITISH PATENT 908,788 (1962 TO GEIGY)
PREPN OF HYDROCHLORIDE: BELGIAN PATENT 614,616, CA 58 11338C (1963), (1962 TO GEIGY)
Desipramine is a tricyclic antidepressant (TCA) classified as a secondary amine (see Image. Desipramine Skeletal Formula). Compared to tertiary amines such as amitriptyline, desipramine is associated with fewer anticholinergic adverse effects.
Desipramine is an oral tricyclic antidepressant that widely used in the therapy of depression. Desipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Antidepressive Agents, Tricyclic

Synonyms

desipramine; Norimipramine; 50-47-5; Desmethylimipramine; Monodemethylimipramine; Desipramin; Demethylimipramine; Desimipramine; Dimethylimipramine; Dezipramine; Desipramina; Methylaminopropyliminodibenzyl; Imipramine, demethyl-; desipraminum; Desimpramine; 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE

Frequently Asked Questions

What are the CAS number and molecular formula of desipramine?

CAS 50-47-5; molecular formula C18H22N2; molecular weight — g/mol.

What other names is desipramine known by?

desipramine, Norimipramine, 50-47-5, Desmethylimipramine, Monodemethylimipramine, Desipramin.

Is desipramine classified as hazardous?

Hazard statements reported: H302, H336, H370, H400.

What are the key physical properties of desipramine?

Boiling Point: 172-174 °C @ 0.02 MM HG; Melting Point: 214-218 °C; Melting Point: 214 - 218 °C; Solubility: 58.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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