地诺孕烯

Description

Dienogestrel · CAS 65928-58-7 · C20H25NO2. UNII 46M3EV8HHE. Melting Point: 210-218.

Identification

CAS Registry Number	65928-58-7
PubChem CID	68861
Molecular formula	C20H25NO2
IUPAC name	2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile
UNII (FDA)	46M3EV8HHE

Computed Descriptors

Molecular Weight	311.4
XLogP3	1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	311.188529040
Monoisotopic Mass	311.188529040
Topological Polar Surface Area	61.1
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	210-218

Physical description & handling notes

• Practically insoluble

GHS Hazard Classification

Reported hazard statements	H315 (10%), H319 (10%), H335 (10%), H341 (10%), H351 (50%), H360 (50%), H361 (40%), H362 (40%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Indicated for use as the treatment of endometriosis alone and as a contraceptive in combination with ethinylestradiol.
• Breast Feeding; Lactation; Milk, Human; Contraceptive Agents, Female; Contraceptives, Oral, Synthetic
• Avoid grapefruit products. Grapefruit inhibits the CYP3A metabolism of dienogest, which may increase its serum concentration.
• Avoid St. John's Wort. This herb induces the CYP3A metabolism of dienogest and may reduce its serum concentration.

Synonyms

Dienogest; 65928-58-7; Dienogestril; Dienogestum; Endometrion; STS 557; STS-557; MJR-35; 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 46M3EV8HHE; ZK 37659; M 18575; M-18575; 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one; 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17alpha)-; ZK-37659

Frequently Asked Questions

What are the CAS number and molecular formula of Dienogestrel?

CAS 65928-58-7; molecular formula C20H25NO2; molecular weight — g/mol.

What other names is Dienogestrel known by?

Dienogest, 65928-58-7, Dienogestril, Dienogestum, Endometrion, STS 557.

Is Dienogestrel classified as hazardous?

Hazard statements reported: H315, H319, H335, H341, H351.

What are the key physical properties of Dienogestrel?

Melting Point: 210-218.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.