difenidol

Description

difenidol · CAS 972-02-1 · C21H27NO. UNII NQO8R319LY. Melting Point: 212-214; Melting Point: 104-105 °C; Solubility: 5.87e-03 g/L.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• NEEDLES FROM PETROLEUM ETHER
• WHITE CRYSTALLINE POWDER
• ODORLESS
• SLIGHTLY BITTER TASTE
• CRYSTALS FROM CHLOROFORM + ETHYL ACETATE; FREELY SOL IN METHANOL; SOL IN WATER & CHLOROFORM; PRACTICALLY INSOL IN ETHER, BENZENE, & PETROLEUM ETHER /HCL/

Documented Uses

• MIESCHER, MARXER, US PATENT 2,411,644 (1946 TO CIBA); BARRETT, WILKINSON, BRITISH PATENT 683,950 (1952 TO WELLCOME FOUNDATION), CA 48, 2112E (1954).
• DIPHENIDOL IS DISSOLVED IN SUITABLE SOLVENT & REACTED WITH HYDROGEN CHLORIDE. /HCL/
• For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.
• Antiemetics; Histamine H1 Antagonists
• ...ANTIEMETIC AGENT FOR ORAL, RECTAL, IM, OR IV ADMIN, USEFUL IN MGMNT OF NAUSEA & VOMITING ASSOC WITH INFECTIOUS DISEASES, MALIGNANCIES, RADIATION SICKNESS, GENERAL ANESTHESIA, TREATMENT WITH ANTINEOPLASTIC AGENTS. ...ALSO USEFUL IN TREATMENT OF VERTIGO OF VESTIBULAR ORIGIN.
• IN ADULTS, THIS DRUG ALSO IS EFFECTIVE IN...LABYRINTHITIS FOLLOWING SURGERY OF MIDDLE & INNER EAR, & MENIERE'S DISEASE. ITS USE IN TREATMENT OF VERTIGO IN CHILDREN HAS NOT BEEN INVESTIGATED. /HCL/

Synonyms

DIPHENIDOL; Difenidol; 972-02-1; Nometic; Avomol; Difenidolo; Difenidolum; 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol; alpha,alpha-Diphenyl-1-piperidinebutanol; Diphenyl(3-(1-piperidyl)propyl)carbinol; SKF 478; SK&F 478; SK&F-478; SK-478; DTXSID3022950; NQO8R319LY

Frequently Asked Questions

What are the CAS number and molecular formula of difenidol?

CAS 972-02-1; molecular formula C21H27NO; molecular weight — g/mol.

What other names is difenidol known by?

DIPHENIDOL, Difenidol, 972-02-1, Nometic, Avomol, Difenidolo.

What are the key physical properties of difenidol?

Melting Point: 212-214; Melting Point: 104-105 °C; Solubility: 5.87e-03 g/L; LogP: 4.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.