屈丙嗪

Description

Dropropizine · CAS 17692-31-8 · C13H20N2O2. UNII U0K8WHL37U. LogP: 0.84.

Identification

CAS Registry Number	17692-31-8
PubChem CID	3169
Molecular formula	C13H20N2O2
IUPAC name	3-(4-phenylpiperazin-1-yl)propane-1,2-diol
UNII (FDA)	U0K8WHL37U

Computed Descriptors

Molecular Weight	236.31
XLogP3	0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	236.152477885
Monoisotopic Mass	236.152477885
Topological Polar Surface Area	46.9
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

LogP	0.84

Physical description & handling notes

• >35.4 [ug/mL] (The mean of the results at pH 7.4)
• 155.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 149.01 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 155.09 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 154.54 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 158.03 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
• R05 - Cough and cold preparations
• R05D - Cough suppressants, excl. combinations with expectorants
• R05DB - Other cough suppressants

Synonyms

dropropizine; 17692-31-8; 3-(4-phenylpiperazin-1-yl)propane-1,2-diol; Dipropizine; Catabex; Katril; Ditustat; Tussilex; Larylin; Ribex; Dopropizin; (+-)-Dropropizine; Dropropizina; Dropropizinum; 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-; 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

Frequently Asked Questions

What are the CAS number and molecular formula of Dropropizine?

CAS 17692-31-8; molecular formula C13H20N2O2; molecular weight — g/mol.

What other names is Dropropizine known by?

dropropizine, 17692-31-8, 3-(4-phenylpiperazin-1-yl)propane-1,2-diol, Dipropizine, Catabex, Katril.

Is Dropropizine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Dropropizine?

LogP: 0.84.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.