Dulcin

Description

4-ethoxyphenylurea · CAS 150-69-6 · C9H12N2O2. UNII 8U78KF577Z. Melting Point: 343 to 345 °F (NTP, 1992); Melting Point: 173.5 °C; Melting Point: 173 - 174 °C.

Identification

CAS Registry Number	150-69-6
PubChem CID	9013
Molecular formula	C9H12N2O2
IUPAC name	(4-ethoxyphenyl)urea
UNII (FDA)	8U78KF577Z

Computed Descriptors

Molecular Weight	180.20
XLogP3	1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	180.089877630
Monoisotopic Mass	180.089877630
Topological Polar Surface Area	64.4
Heavy Atom Count	13
Formal Charge	0

Physical & Chemical Properties

Melting Point	343 to 345 °F (NTP, 1992)
Melting Point	173.5 °C
Melting Point	173 - 174 °C
Solubility	In water, 1.21 g/L at 21 °C
Solubility	1.21 mg/mL at 21 °C

Physical description & handling notes

• Dulcin appears as white crystals. (NTP, 1992)
• Solid
• White needle-like crystals or powder
• Lustrous needles
• Leafs (from dilute alcohol), plates (from water)
• Very sweet taste, about 250 times as sweet as sugar cane

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: NON-NUTRITIVE SWEETENER SWEETENER: Food Additives DULCIN--PROHIBITED NOT TO BE USED NMRS 44/TRS 383-JECFA 11/13 FAS 68.33/NMRS 44A-JECFA 11/100

GHS Hazard Classification

Reported hazard statements	H302 (50%), H315 (50%), H319 (50%)

Documented Uses

• Artificial sweetening agent, prohibited by FDA for use in foods.
• Food Additives -> SWEETENER -> JECFA Functional Classes
• ... Produced from the addition of potassium cyanate to p-phenetidine hydrochloride in aqueous solution at room temperature or from mixing urea and p-phenetidine hydrochloride to a mixture of hydrochloric acid and glacial acetic acid.
• Made by treating p-phenetidine with phosgene and then with ammonia.
• Dulcin achieved some practical importance as a sweetener, despite safety concerns. It was blended with saccharin or sodium saccharin in order to mask the aftertaste of saccharin. As some dulcin metabolites were considered potentially hazardous, it is now banned in most countries.
• Compared with dilute sucrose solutions, it is approximately 250 times sweeter. Sweetness characteristics are good.

Synonyms

Dulcin; 150-69-6; 1-(4-Ethoxyphenyl)urea; (4-ethoxyphenyl)urea; N-(4-Ethoxyphenyl)urea; Sucrol; Valzin; p-Ethoxyphenylurea; Dulcine; Phenetolcarbamide; Suesstoff; p-Phenetolcarbamide; p-Phenetylurea; p-Phenetolecarbamide; 4-ETHOXYPHENYLUREA; p-Phenetolcarbamid

Frequently Asked Questions

What are the CAS number and molecular formula of 4-ethoxyphenylurea?

CAS 150-69-6; molecular formula C9H12N2O2; molecular weight — g/mol.

What other names is 4-ethoxyphenylurea known by?

Dulcin, 150-69-6, 1-(4-Ethoxyphenyl)urea, (4-ethoxyphenyl)urea, N-(4-Ethoxyphenyl)urea, Sucrol.

What is the regulatory status of 4-ethoxyphenylurea?

Documented regulatory listings: FDA Substance added to food: NON-NUTRITIVE SWEETENER; SWEETENER: Food Additives; DULCIN--PROHIBITED.

Is 4-ethoxyphenylurea classified as hazardous?

Hazard statements reported: H302, H315, H319.

What are the key physical properties of 4-ethoxyphenylurea?

Melting Point: 343 to 345 °F (NTP, 1992); Melting Point: 173.5 °C; Melting Point: 173 - 174 °C; Solubility: In water, 1.21 g/L at 21 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.