Econazole

Description

Econazole · CAS 27220-47-9 · C18H15Cl3N2O. UNII 6Z1Y2V4A7M. Melting Point: 162; Solubility: 1.48e-03 g/L; LogP: 5.5.

Identification

CAS Registry Number	27220-47-9
PubChem CID	3198
Molecular formula	C18H15Cl3N2O
IUPAC name	1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
UNII (FDA)	6Z1Y2V4A7M

Computed Descriptors

Molecular Weight	381.7
XLogP3	5.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	380.024996
Monoisotopic Mass	380.024996
Topological Polar Surface Area	27.1
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	162
Solubility	1.48e-03 g/L
LogP	5.5

Physical description & handling notes

• Solid
• 185.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6025226]
• 193.2 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6025226]
• 185.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID6025226]
• 182.89 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

Regulatory Status

GHS notification summary	2.6% (1 / 39)

GHS Hazard Classification

GHS notification summary	2.6% (1 / 39)
Reported hazard statements	H302 (97.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Trichophyton tonsurans</i>, <i>Microsporum canis</i>, <i>Microsporum audouini</i>, <i>Microsporum gypseum</i>, and <i>Epidermophyton floccosum</i>, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
• Breast Feeding; Lactation; Milk, Human; Antifungal Agents; Anti-Infective Agents
• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
• Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.

Synonyms

econazole; 27220-47-9; Econazolum; Econazol; (+-)-Econazole; 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; NSC-187789; 6Z1Y2V4A7M; DTXSID2029872; 1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole; 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-; Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-; 1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-; econazolo

Frequently Asked Questions

What are the CAS number and molecular formula of Econazole?

CAS 27220-47-9; molecular formula C18H15Cl3N2O; molecular weight — g/mol.

What other names is Econazole known by?

econazole, 27220-47-9, Econazolum, Econazol, (+-)-Econazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole.

Is Econazole classified as hazardous?

2.6% of GHS notifications report no hazard classification (1 of 39).

What are the key physical properties of Econazole?

Melting Point: 162; Solubility: 1.48e-03 g/L; LogP: 5.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.