Enasidenib

Description

Enasidenib · CAS 1446502-11-9 · C19H17F6N7O. UNII 3T1SS4E7AG.

Identification

CAS Registry Number	1446502-11-9
PubChem CID	89683805
Molecular formula	C19H17F6N7O
IUPAC name	2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol
UNII (FDA)	3T1SS4E7AG

Computed Descriptors

Molecular Weight	473.4
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	6
Exact Mass	473.13987716
Monoisotopic Mass	473.13987716
Topological Polar Surface Area	109
Heavy Atom Count	33
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H360 (50%), H373 (100%), H413 (50%)

Documented Uses

• Enasidenib is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test.
• Enasidenib is an orally available small molecule inhibitor of mutant isocitrate dehydrogenase-2 that is used in the therapy of selected cases of acute myelogenous leukemia (AML). Enasidenib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Isocitrate Dehydrogenase Inhibitors
• Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
• Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
• Take at the same time every day.

Synonyms

Enasidenib; 1446502-11-9; CC-90007 Free Base; enasidenibum; 3T1SS4E7AG; CHEBI:145374; DTXSID801027942; RefChem:58279; L01XX59; DTXCID401513509; 107-597-8; AG-221; IDHIFA; AG-221 (Enasidenib); Enasidenib [INN]; AG 221

Frequently Asked Questions

What are the CAS number and molecular formula of Enasidenib?

CAS 1446502-11-9; molecular formula C19H17F6N7O; molecular weight — g/mol.

What other names is Enasidenib known by?

Enasidenib, 1446502-11-9, CC-90007 Free Base, enasidenibum, 3T1SS4E7AG, CHEBI:145374.

Is Enasidenib classified as hazardous?

Hazard statements reported: H360, H373, H413.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.