盐酸艾司洛尔

Description

Esmolol hydrochloride · CAS 81161-17-3 · C16H26ClNO4. UNII V05260LC8D. Melting Point: 85-86 °C; Dissociation Constants: pKa = 9.5.

Identification

CAS Registry Number	81161-17-3
PubChem CID	104769
Molecular formula	C16H26ClNO4
IUPAC name	methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate;hydrochloride
UNII (FDA)	V05260LC8D

Computed Descriptors

Molecular Weight	331.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	331.1550360
Monoisotopic Mass	331.1550360
Topological Polar Surface Area	67.8
Heavy Atom Count	22
Formal Charge	0
Complexity	288

Physical & Chemical Properties

Melting Point	85-86 °C
Dissociation Constants	pKa = 9.5

Physical description & handling notes

• White or off-white crystalline powder
• Crystals from methanol-ether
• Esmolol hydrochloride concentrate for injection should be stored at 15-30 °C. /Esmolol hydrochloride/
• Esmolol hydrochloride concentrate for injection ... /should not be exposed/ to temperatures of 40 °C or higher. /Esmolol hydrochloride/
• At a concentration of 10 mg/ml, esmolol hydrochloride is chemically and physically stable for at least 24 hours at 15-30 °C or when refrigerated in the following IV solutions; 5% dextrose; 5% dextrose and Ringer's or lactated Ringer's, 5% dextrose and 0.45 or 0.9% sodium chloride; lactated Ringer's; or 0.45 or 0.9% sodium; or 5% dextrose and potassium chloride 40 mEq/l.
• In alcohol, 350 mg/l at room temperature

GHS Hazard Classification

Reported hazard statements	H301 (18.8%), H311 (18.8%), H319 (81.2%), H331 (18.8%)

Documented Uses

• Esmolol is used IV principally to provide rapid, temporary control of ventricular rate in patients with supraventricular tachyarrhythmias (SVT) (eg, atrial flutter and/or fibrillation, sinus tachycardia).
• Esmolol may be preferred to longer-acting B-adrenergic blocking agents for the short-term control of ventricular rate in patients with SVT because of the drug's rapid onset and short duration of effects, ... .
• For more Therapeutic Uses (Complete) data for ESMOLOL HYDROCHLORIDE (6 total), please visit the HSDB record page.
• ... Esmolol is contraindicated in patients with second- or third-degree atrioventricular blocks, sinus bradycardia, cardiogenic shock, or overt cardiac failure.
• Esmolol may mask signs and symptoms of hypoglycemia (eg, tachycardia, palpitation, blood pressure changes, tremor, feelings of anxiety, but not sweating or dizziness) and may potentiate insulin-induced hypoglycemia; therefore, the drug should be used with caution in patients with diabetes mellitus or hypoglycemia.
• Because of de-esterified metabolite (ASL 8123) of esmolol is eliminated mainly by the kidneys, ... the drug should be used with caution in patients with renal impairment, especially severe impairment.

Synonyms

Esmolol hydrochloride; 81161-17-3; Esmolol HCL; Brevibloc; ASL-8052; Asl 8052; DTXSID7049003; Brevibloc in plastic container; V05260LC8D; DTXCID8028929; Brevibloc Double Strength in plastic container; (+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate hydrochloride; 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic acid methyl ester HCl; Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride; CHEBI:4857; RefChem:56564

Frequently Asked Questions

What are the CAS number and molecular formula of Esmolol hydrochloride?

CAS 81161-17-3; molecular formula C16H26ClNO4; molecular weight — g/mol.

What other names is Esmolol hydrochloride known by?

Esmolol hydrochloride, 81161-17-3, Esmolol HCL, Brevibloc, ASL-8052, Asl 8052.

Is Esmolol hydrochloride classified as hazardous?

Hazard statements reported: H301, H311, H319, H331.

What are the key physical properties of Esmolol hydrochloride?

Melting Point: 85-86 °C; Dissociation Constants: pKa = 9.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.