Esomeprazole

Description

Esomeprazole · CAS 119141-88-7 · C17H19N3O3S. UNII N3PA6559FT. Melting Point: 155; LogP: 0.6.

Identification

CAS Registry Number	119141-88-7
PubChem CID	9568614
Molecular formula	C17H19N3O3S
IUPAC name	6-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole
UNII (FDA)	N3PA6559FT

Computed Descriptors

Molecular Weight	345.4
XLogP3	2.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	345.11471265
Monoisotopic Mass	345.11471265
Topological Polar Surface Area	96.3
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	155
LogP	0.6

Physical description & handling notes

• Solid
• Very slightly soluble in water
• Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Magnesium oxide
• White to slightly colored crystalline powder. Slightly soluble in water; stability ... is a function of pH; it degrades rapidly in acidic media but has acceptable stability under alkaline conditions; half-lives of 19 and 8 hrs at 25 and 37 °C, respectively /Esomeprazole magnesium/
• White to almost white crystalline powder; soluble in water /Esomeprazole strontium/
• ... for injection is supplied as a sterile, freeze-dried, white to off-white, porous cake or powder. ... The stability of esomeprazole sodium in aqueous solution is strongly pH dependent. /Esomeprazole sodium/

GHS Hazard Classification

Reported hazard statements	H312 (100%), H315 (100%), H317 (100%), H319 (100%), H335 (100%), H412 (100%)

Documented Uses

• Anti-Ulcer Agents; Proton Pump Inhibitors
• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita) in the USA (2002): 0.0425
• Used in the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use. Used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. [Wikipedia]
• Omeprazole is indicated for the treatment of duodenal ulcers, benign gastric ulcers, gastroesophageal reflux disease (GERD), heartburn and other symptoms associated with GERD, erosive esophagitis, and long-term treatment of pathological hypersecretory conditions like Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis.

Synonyms

Esomeprazole; 119141-88-7; (S)-Omeprazole; (-)-Omeprazole; Inexium paranova; (S)-(-)-Omeprazole; esomeprazol; esomeprazolum; Alenia; Esofag; Escz; Nexiam; Omeprazole, (s)-; Perprazole; Esopral; Axagon

Frequently Asked Questions

What are the CAS number and molecular formula of Esomeprazole?

CAS 119141-88-7; molecular formula C17H19N3O3S; molecular weight — g/mol.

What other names is Esomeprazole known by?

Esomeprazole, 119141-88-7, (S)-Omeprazole, (-)-Omeprazole, Inexium paranova, (S)-(-)-Omeprazole.

Is Esomeprazole classified as hazardous?

Hazard statements reported: H312, H315, H317, H319, H335.

What are the key physical properties of Esomeprazole?

Melting Point: 155; LogP: 0.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.