雌二醇

Description

Estradiol · CAS 50-28-2 · C18H24O2. UNII 4TI98Z838E. Boiling Point: 445.9±45.0; Melting Point: 173; Melting Point: 178.5 °C.

Identification

CAS Registry Number	50-28-2
PubChem CID	5757
Molecular formula	C18H24O2
IUPAC name	(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
UNII (FDA)	4TI98Z838E

Computed Descriptors

Molecular Weight	272.4
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	272.177630004
Monoisotopic Mass	272.177630004
Topological Polar Surface Area	40.5
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Boiling Point	445.9±45.0
Melting Point	173
Melting Point	178.5 °C
Melting Point	178-179 °C
Solubility	3.6
Solubility	In water, 3.90 mg/L at 27 °C
Solubility	0.0036 mg/mL
LogP	4.01
LogP	3.15
Dissociation Constants	10.46±0.03

Physical description & handling notes

• Solid
• White powder.
• White crystalline powder. Prisms from 80% alcohol
• White or slightly yellow, small crystals or crystalline powder
• Odorless
• Very soluble in acetone, ethanol, dioxane

Regulatory Status

Regulatory & Food Contact	PRODUCTION_AID: Veterinary Drug 0-50 ng/kg bw TRS 893-JECFA 52/57 FAS 43-JECFA 52/43

GHS Hazard Classification

Reported hazard statements	H350 (39.6%), H351 (57.9%), H360 (82.4%), H362 (32.7%), H372 (34.6%), H400 (30.8%), H410 (36.5%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.00183
• For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Veterinary Drug -> PRODUCTION_AID -> JECFA Functional Classes

Synonyms

estradiol; beta-Estradiol; 50-28-2; 17beta-Estradiol; Oestradiol; Estrace; Dihydrofolliculin; Aquadiol; Diogynets; Divigel; Vivelle; Diogyn; Dihydrotheelin; Dihydroxyestrin; Dimenformon; Estraderm

Frequently Asked Questions

What are the CAS number and molecular formula of Estradiol?

CAS 50-28-2; molecular formula C18H24O2; molecular weight — g/mol.

What other names is Estradiol known by?

estradiol, beta-Estradiol, 50-28-2, 17beta-Estradiol, Oestradiol, Estrace.

What is the regulatory status of Estradiol?

Documented regulatory listings: PRODUCTION_AID: Veterinary Drug; 0-50 ng/kg bw; TRS 893-JECFA 52/57.

Is Estradiol classified as hazardous?

Hazard statements reported: H350, H351, H360, H362, H372.

What are the key physical properties of Estradiol?

Boiling Point: 445.9±45.0; Melting Point: 173; Melting Point: 178.5 °C; Melting Point: 178-179 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.