Famciclovir

Description

Famciclovir · CAS 104227-87-4 · C14H19N5O4. UNII QIC03ANI02. Melting Point: 102-104 °C; Melting Point: 102 - 104 °C; Solubility: 1.32e+00 g/L.

Identification

CAS Registry Number	104227-87-4
PubChem CID	3324
Molecular formula	C14H19N5O4
IUPAC name	[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
UNII (FDA)	QIC03ANI02

Computed Descriptors

Molecular Weight	321.33
XLogP3	0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	321.14370410
Monoisotopic Mass	321.14370410
Topological Polar Surface Area	122
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	102-104 °C
Melting Point	102 - 104 °C
Solubility	1.32e+00 g/L
LogP	0.6
LogP	0.32

Physical description & handling notes

• Solid
• White shiny plates from ethyl acetate-hexane
• Solubility in water (25 °C): > 25% w/v initially; rapidly precipitates as sparingly soluble monohydrate (2-3% w/v)
• Freely soluble in acetone, methanol; sparingly soluble in ethanol, isopropanol
• When heated to decomposition material emits toxic fumes of /nitrogen oxides/.
• 167.77 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H319 (50%), H341 (25%), H351 (25%), H360 (50%)

Documented Uses

• Used in the treatment of herpes simplex virus (HSV), varcilla zoster virus (VZV), and cytomegalovirus (CMV)
• Use (kg; approx.) in Germany (2009): >50
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• Consumption (g per capita) in the USA (2002): 0.0329
• Categorized under nucleoside analog groups which inhibit viral DNA polymerase
• For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.

Synonyms

famciclovir; 104227-87-4; Famvir; BRL-42810; Famciclovirum; BRL 42810; [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; DTXSID0023038; 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; BRL42810; QIC03ANI02; 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine; NSC-758921; CHEBI:4974; 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester); 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester)

Frequently Asked Questions

What are the CAS number and molecular formula of Famciclovir?

CAS 104227-87-4; molecular formula C14H19N5O4; molecular weight — g/mol.

What other names is Famciclovir known by?

famciclovir, 104227-87-4, Famvir, BRL-42810, Famciclovirum, BRL 42810.

Is Famciclovir classified as hazardous?

Hazard statements reported: H319, H341, H351, H360.

What are the key physical properties of Famciclovir?

Melting Point: 102-104 °C; Melting Point: 102 - 104 °C; Solubility: 1.32e+00 g/L; LogP: 0.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.