醋酸氟卡尼

Description

flecainide acetate · CAS 54143-56-5 · C17H20F6N2O3. UNII K94FTS1806. Melting Point: 228-229; Solubility: 48.4; Solubility: 3.24e-02 g/L.

Identification

CAS Registry Number	54143-56-5
PubChem CID	3356
Molecular formula	C17H20F6N2O3
IUPAC name	N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
UNII (FDA)	K94FTS1806

Computed Descriptors

Molecular Weight	414.34
XLogP3	3.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	414.13781148
Monoisotopic Mass	414.13781148
Topological Polar Surface Area	59.6
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Melting Point	228-229
Solubility	48.4
Solubility	3.24e-02 g/L
LogP	3.78
LogP	4.6
Dissociation Constants	9.3

Physical description & handling notes

• Solid
• 192.2 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• Flecainide inhibits the action of sodium and potassium ion channels in the heart, raising the threshold for depolarization and correcting arrhythmias. Flecainide has a long duration of action, allowing for once daily dosing. The therapeutic index is narrow. Patients should not take this medication if there is already structural heart disease or left ventricular systolic dysfunction.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H336 (50%), H361 (50%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Flecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin (A308).
• In New Zealand and America, flecainide is indicated to prevent supraventricular arrhythmias and ventricular arrhythmias. In the United States, it is also indicated to prevent paroxysmal atrial fibrillation and flutter.
• Flecainide acetate is an oral Class Ic antiarrhythmic drug that blocks cardiac sodium (Na+) channels and was approved by the US Food and Drug Administration (FDA) in 1984.
• Flecainide is an oral antiarrhythmic agent that has been in use for several decades. Long term flecainide therapy is associated with a low rate of serum enzyme elevations and is a very rare cause of clinically apparent acute liver injury.

Synonyms

flecainide; 54143-55-4; Flecaine; N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide; Flecainida; Flecainidum; (+-)-Flecainide; N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide; CCRIS 313; Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-; DTXSID8023054; NSC-719273; K94FTS1806; DTXCID403054; CHEBI:75984; THN-102 COMPONENT FLECAINIDE

Frequently Asked Questions

What are the CAS number and molecular formula of flecainide acetate?

CAS 54143-56-5; molecular formula C17H20F6N2O3; molecular weight — g/mol.

What other names is flecainide acetate known by?

flecainide, 54143-55-4, Flecaine, N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide, Flecainida, Flecainidum.

Is flecainide acetate classified as hazardous?

Hazard statements reported: H302, H336, H361.

What are the key physical properties of flecainide acetate?

Melting Point: 228-229; Solubility: 48.4; Solubility: 3.24e-02 g/L; LogP: 3.78.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.