Fleroxacin

Description

Fleroxacin · CAS 79660-72-3 · C17H18F3N3O3. UNII N804LDH51K. Melting Point: 270; LogP: 0.24; LogP: 0.04.

Identification

CAS Registry Number	79660-72-3
PubChem CID	3357
Molecular formula	C17H18F3N3O3
IUPAC name	6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
UNII (FDA)	N804LDH51K

Computed Descriptors

Molecular Weight	369.34
XLogP3	-0.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Exact Mass	369.13002593
Monoisotopic Mass	369.13002593
Topological Polar Surface Area	64.1
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	270
LogP	0.24
LogP	0.04
Dissociation Constants	8.8
Dissociation Constants	5.5
Dissociation Constants	8.2

Physical description & handling notes

• 198.8 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 189.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.

GHS Hazard Classification

Reported hazard statements	H371 (100%)

Documented Uses

• Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
• Take with a full glass of water.
• Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
• Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
• J - Antiinfectives for systemic use
• J01 - Antibacterials for systemic use

Synonyms

fleroxacin; 79660-72-3; Megalone; Megalocin; Fleroxicin; Fleroxacino; Quinodis; Fleroxacine; Fleroxacinum; AM-833; AM 833; FLRX; 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; Ro 23-6240/000; DTXSID1046714; Ro-236240

Frequently Asked Questions

What are the CAS number and molecular formula of Fleroxacin?

CAS 79660-72-3; molecular formula C17H18F3N3O3; molecular weight — g/mol.

What other names is Fleroxacin known by?

fleroxacin, 79660-72-3, Megalone, Megalocin, Fleroxicin, Fleroxacino.

Is Fleroxacin classified as hazardous?

Hazard statements reported: H371.

What are the key physical properties of Fleroxacin?

Melting Point: 270; LogP: 0.24; LogP: 0.04; Dissociation Constants: 8.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.