Flutamide

Description

Flutamide · CAS 13311-84-7 · C11H11F3N2O3. UNII 76W6J0943E. Melting Point: 111.5-112.5; Melting Point: 111 - 113 °C; Solubility: 9.45.

Identification

CAS Registry Number	13311-84-7
PubChem CID	3397
Molecular formula	C11H11F3N2O3
IUPAC name	2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
UNII (FDA)	76W6J0943E

Computed Descriptors

Molecular Weight	276.21
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	276.07217670
Monoisotopic Mass	276.07217670
Topological Polar Surface Area	74.9
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	111.5-112.5
Melting Point	111 - 113 °C
Solubility	9.45
Solubility	5.66e-03 g/L
LogP	3.35
LogP	2.6

Physical description & handling notes

• Solid
• >41.4 [ug/mL] (The mean of the results at pH 7.4)
• 154.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID7032004]
• 160 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 154.25 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 158.18 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302, H312, H332 (29.8%), H360 (13.8%), H361 (84%), H373 (12.8%), H413 (10.6%), H372

Documented Uses

• Use (kg; approx.) in Germany (2009): >1000
• Use (kg; exact) in Germany (2009): 1266
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita; exact) in Germany (2009): 0.0155
• For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
• Flutamide is indicated by the US-FDA for the adult population only to treat stage B2-C and stage D2 metastatic carcinoma of the prostate.

Synonyms

flutamide; 13311-84-7; Eulexin; Niftolide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Sch 13521; NFBA; niftolid; Drogenil; Flutamida; Flutamidum; Sch-13521; 4'-Nitro-3'-trifluoromethylisobutyranilide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; Eulexine; Propanamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-

Frequently Asked Questions

What are the CAS number and molecular formula of Flutamide?

CAS 13311-84-7; molecular formula C11H11F3N2O3; molecular weight — g/mol.

What other names is Flutamide known by?

flutamide, 13311-84-7, Eulexin, Niftolide, 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, Sch 13521.

Is Flutamide classified as hazardous?

Hazard statements reported: H302, H312, H332, H360, H361.

What are the key physical properties of Flutamide?

Melting Point: 111.5-112.5; Melting Point: 111 - 113 °C; Solubility: 9.45; Solubility: 5.66e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.