Fluticasone Furoate

Description

Fluticasone Furoate · CAS 397864-44-7 · C27H29F3O6S. UNII JS86977WNV. Melting Point: 250-252.

Identification

CAS Registry Number	397864-44-7
PubChem CID	9854489
Molecular formula	C27H29F3O6S
IUPAC name	[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
UNII (FDA)	JS86977WNV

Computed Descriptors

Molecular Weight	538.6
XLogP3	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	538.16369430
Monoisotopic Mass	538.16369430
Topological Polar Surface Area	119
Heavy Atom Count	37
Formal Charge	0

Physical & Chemical Properties

Melting Point	250-252

Physical description & handling notes

• Insoluble

GHS Hazard Classification

Reported hazard statements	H360 (42.9%), H361 (35.7%), H373 (71.4%), H410 (42.9%)

Documented Uses

• Fluticasone furoate is indicated for once-daily maintenance (i.e. prophylactic) treatment of asthma in patients ≥5 years old. Fluticasone furoate is available in two combination medications - one in combination with [vilanterol] and one in combination with both vilanterol and [umeclidinium]- which are both indicated for the management of chronic obstructive pulmonary disease (COPD) and for the treatment of asthma in patients ≥18 years old for the vilanterol-umeclidinium-fluticasone product and ≥5 years old for the
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]
• R03 - Drugs for obstructive airway diseases
• R03B - Other drugs for obstructive airway diseases, inhalants
• R01A - Decongestants and other nasal preparations for topical use
• QR01A - Decongestants and other nasal preparations for topical use

Synonyms

Fluticasone furoate; 397864-44-7; Veramyst; Allermist; Avamys; Furamist; Arnuity Ellipta; Ennhale; Flonase Sensimist; GSK 685 698; furoate de fluticasone; furoato de fluticasona; fluticasonum furoas; GW685698X; GSK 685698; GW-685698X

Frequently Asked Questions

What are the CAS number and molecular formula of Fluticasone Furoate?

CAS 397864-44-7; molecular formula C27H29F3O6S; molecular weight — g/mol.

What other names is Fluticasone Furoate known by?

Fluticasone furoate, 397864-44-7, Veramyst, Allermist, Avamys, Furamist.

Is Fluticasone Furoate classified as hazardous?

Hazard statements reported: H360, H361, H373, H410.

What are the key physical properties of Fluticasone Furoate?

Melting Point: 250-252.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.