GHK

Description

GHK · CAS 1227510-36-2 · C14H24N6O4. UNII 39TG2H631E.

Identification

Computed Descriptors

Physical description & handling notes

• Prezatide in complex with copper improve skin elasticity, density, and firmness, reduces fine lines and wrinkles, reduces photodamage, increases keratinocyte proliferation. Prezatide also displays anti-oxidant and angiogenic effects and appears to modulate tissue remodeling in injury.

Regulatory Status

Documented Uses

• Commonly used in cosmetic products for the skin and hair.
• Prezatide both free and in complex with copper can pass through the stratum corneum. Its absorption is pH dependent with the highest absorption occurring at physiological pH.
• Prezatide is broken down to histidyl-lysine which is likely further degraded to other metabolites of proteolysis.
• Prezatide is rapidly eliminated within minutes.
• Prezatide in complex with copper increases the synthesis and deposition of type I collagen and glycosaminoglycan. It also increases the expression of matrix metalloproteinase-2 as well as tissue inhibitor of matrix metalloproteinases-1 and -2, suggesting that it plays a role in the modulation of tissue remodeling. It is thought that prezatide's antioxidant activity is due to its ability to supply copper for superoxide dismutase and its anti inflammatory ability due to the blockage the of iron (Fe2+) release during

Synonyms

glycyl-l-histidyl-l-lysine; 49557-75-7; Prezatide; Liver cell growth factor; Glycyl-histidyl-lysine; Copper(II)ghk; KOLLAREN; 39TG2H631E; PC-1020 FREE BASE; ORISTAR GHK; Growth-modulating peptide (human); DTXSID30197831; NSC-379527; N(2)-(N-Glycyl-L-histidyl)-L-lysine; Natural Cedarwood Oil; RefChem:868497

Frequently Asked Questions

What are the CAS number and molecular formula of GHK?

CAS 1227510-36-2; molecular formula C14H24N6O4; molecular weight — g/mol.

What other names is GHK known by?

glycyl-l-histidyl-l-lysine, 49557-75-7, Prezatide, Liver cell growth factor, Glycyl-histidyl-lysine, Copper(II)ghk.

What is the regulatory status of GHK?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Tripeptide-1) -> CIR (Cosmetic Ingredient Review).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.