吉特替尼

Name: 吉特替尼
Brand: 济南圣和化工有限公司

CAS 1254053-43-4C29H44N8O3MW 552.7

吉特替尼，CAS 登记号 1254053-43-4，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于有机化学品。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号1254053-43-4

分子式C29H44N8O3

分子量552.7

沸点696

LogP4.35

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域有机化学品

类别有机化学品

用途与场景

有机化学品

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

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常见问题

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本页已列出吉特替尼的 CAS 号：1254053-43-4，可与随货 COA 核对。

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主要涉及有机化学品。

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PubChem 公开数据

Description

Gilteritinib · CAS 1254053-43-4 · C29H44N8O3. UNII 66D92MGC8M. Boiling Point: 696; Solubility: <1 mg/mL; LogP: 4.35.

Identification

CAS Registry Number	1254053-43-4
PubChem CID	49803313
Molecular formula	C29H44N8O3
IUPAC name	6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
UNII (FDA)	66D92MGC8M

Computed Descriptors

Molecular Weight	552.7
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	552.35363730
Monoisotopic Mass	552.35363730
Topological Polar Surface Area	121
Heavy Atom Count	40
Formal Charge	0

Physical & Chemical Properties

Boiling Point	696
Solubility	<1 mg/mL
LogP	4.35

GHS Hazard Classification

Reported hazard statements	H360 (100%), H373 (100%)

H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Documented Uses

Gilteritinib is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations. Gilteritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of gilteritinib.
Avoid St. John's Wort. This herb induces CYP3A4 and p-glycoprotein, which may reduce the serum concentration of gilteritinib.
Take at the same time every day.
Protein kinase inhibitors that inhibit TYROSINE PROTEIN KINASES.

Synonyms

Gilteritinib; 1254053-43-4; ASP2215; ASP-2215; gilteritinibum; ASP 2215; 66D92MGC8M; CHEBI:145372; DTXSID701027949; RefChem:58108; L01XE54; DTXCID601513517; MFCD28144685; Gilteritinib HCl; Gilteritinib [USAN:INN]; UNII-66D92MGC8M

Frequently Asked Questions

What are the CAS number and molecular formula of Gilteritinib?

CAS 1254053-43-4; molecular formula C29H44N8O3; molecular weight — g/mol.

What other names is Gilteritinib known by?

Gilteritinib, 1254053-43-4, ASP2215, ASP-2215, gilteritinibum, ASP 2215.

Is Gilteritinib classified as hazardous?

Hazard statements reported: H360, H373.

What are the key physical properties of Gilteritinib?

Boiling Point: 696; Solubility: <1 mg/mL; LogP: 4.35.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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