格卡瑞韦

Description

Glecaprevir · CAS 1365970-03-1 · C38H46F4N6O9S. UNII K6BUU8J72P. Solubility: <0.1 to 0.3 mg/mL.

Identification

CAS Registry Number	1365970-03-1
PubChem CID	66828839
Molecular formula	C38H46F4N6O9S
IUPAC name	(1R,14E,18R,22R,26S,29S)-26-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]-13,13-difluoro-24,27-dioxo-2,17,23-trioxa-4,11,25,28-tetrazapentacyclo[26.2.1.03,12.05,10.018,22]hentriaconta-3,5,7,9,11,14-hexaene-29-carboxamide
UNII (FDA)	K6BUU8J72P

Computed Descriptors

Molecular Weight	838.9
XLogP3	4.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	7
Exact Mass	838.29831089
Monoisotopic Mass	838.29831089
Topological Polar Surface Area	204
Heavy Atom Count	58
Formal Charge	0

Physical & Chemical Properties

Solubility	<0.1 to 0.3 mg/mL

Documented Uses

• Indicated for the treatment of adult patients with acute and chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A). MAVYRET is also indicated for the treatment of adult patients with HCV genotype 1 infection, who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor (PI), but not both.
• Breast Feeding; Lactation; Milk, Human; Antiviral Agents; Protease Inhibitors
• Avoid St. John's Wort. Co-administration may lead to decreased serum concentrations of glecaprevir.
• Established Pharmacologic Class [EPC] - Hepatitis C Virus NS3/4A Protease Inhibitor
• Mechanisms of Action [MoA] - HCV NS3/4A Protease Inhibitors
• Mechanisms of Action [MoA] - P-Glycoprotein Inhibitors

Synonyms

Glecaprevir; 1365970-03-1; ABT-493; Maviret; K6BUU8J72P; A-1282576.0; A-1282576; A-12825760; DTXSID901027945; glecaprevirum; RefChem:663069; DTXCID101513512; Glecaprevir [USAN]; BDBM50573891; UNII-K6BUU8J72P; MFCD30533436

Frequently Asked Questions

What are the CAS number and molecular formula of Glecaprevir?

CAS 1365970-03-1; molecular formula C38H46F4N6O9S; molecular weight — g/mol.

What other names is Glecaprevir known by?

Glecaprevir, 1365970-03-1, ABT-493, Maviret, K6BUU8J72P, A-1282576.0.

What are the key physical properties of Glecaprevir?

Solubility: <0.1 to 0.3 mg/mL.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.