格列吡嗪

Description

Glipizide · CAS 29094-61-9 · C21H27N5O4S. UNII X7WDT95N5C. Melting Point: 200-203; Melting Point: 208 - 209 °C; Solubility: 37.2.

Identification

CAS Registry Number	29094-61-9
PubChem CID	3478
Molecular formula	C21H27N5O4S
IUPAC name	N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide
UNII (FDA)	X7WDT95N5C

Computed Descriptors

Molecular Weight	445.5
XLogP3	1.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	445.17837553
Monoisotopic Mass	445.17837553
Topological Polar Surface Area	139
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	200-203
Melting Point	208 - 209 °C
Solubility	37.2
Solubility	1.64e-02 g/L
LogP	1.91
LogP	2.5
LogP	1.64
Dissociation Constants	5.9

Physical description & handling notes

• Solid
• >66.8 [ug/mL] (The mean of the results at pH 7.4)
• 201.4 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID0040676]
• 209.5 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0040676]
• 200.4 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0040676]
• 201.4 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0040676]

Regulatory Status

GHS notification summary	97.7% (43 / 44)

GHS Hazard Classification

GHS notification summary	97.7% (43 / 44)

Documented Uses

• Consumption (g per capita) in the USA (2002): 0.0179
• For use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
• Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Sulfonylurea Compounds
• Avoid excessive or chronic alcohol consumption. The risk of hypoglycemia is increased when alcohol is ingested.
• Take before a meal. Take 30-60 minutes before breakfast.

Synonyms

glipizide; 29094-61-9; Glucotrol; Glydiazinamide; Glibenese; Melizide; Minidiab; Minodiab; Dipazide; Glucozide; Glupitel; Glupizide; Napizide; Sucrazide; Mindiab; Ozidia

Frequently Asked Questions

What are the CAS number and molecular formula of Glipizide?

CAS 29094-61-9; molecular formula C21H27N5O4S; molecular weight — g/mol.

What other names is Glipizide known by?

glipizide, 29094-61-9, Glucotrol, Glydiazinamide, Glibenese, Melizide.

Is Glipizide classified as hazardous?

97.7% of GHS notifications report no hazard classification (43 of 44).

What are the key physical properties of Glipizide?

Melting Point: 200-203; Melting Point: 208 - 209 °C; Solubility: 37.2; Solubility: 1.64e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.